Neutrophil chemotaxis was evaluated in nine patients with juvenile periodontitis, with normal subjects and patients with the adult form of periodontitis as controls. Defective chemotactic responses were observed in neutrophils from seven of nine juvenile patients, and a reduced level of complement-derived chemotactic activity was demonstrated in serum from four patients. These determinations were normal in all the patients with adult periodontitis. Serum from five of the juvenile patients contained a heat-stable, non-dialyzable factor that markedly inhibited the chemotaxis of normal neutrophils. Thus the characteristic tissue destruction seen in juvenile periodontitis may be, at least in part, a consequence of a failure of host defense mechanisms.
Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs
Defective neutrophil chemotaxis in Down's syndrome patients and its relationship to periodontal destruction
Depressed leukotriene B4 chemotactic response of neutrophils from localized juvenile periodontitis patients
Chemiluminescence in the assessment of polymorphonuclear leukocyte function in chronic inflammatory periodontal disease
The polymorphonuclear leukocyte chemotactic response to Bacteroides melaninogenicus. II. Effect of age and periodontal disease status
Suppression of the periodontopathic microflora in localized juvenile periodontitis by systemic tetracycline
Relationship between attachment loss and precipitating serum antibody to Actinobacillus actinomycetemcomitans in adolescents and young adults having severe periodontal destruction
The polymorphonuclear leukocyte (PMNL) locomotor defect in juvenile periodontitis. Study of random migration, chemokinesis and chemotaxis
Neutrophil chemotaxis in individuals with advanced periodontal disease and a genetic predisposition to diabetes mellitus
Comparative antibody titers to Actinobacillus actinomycetemcomitans in juvenile periodontitis, chronic periodontitis and periodontally healthy subjects
Physiopathology of primary periodontitis associated with plaque. Microbial and host factors. A review. Part 2
Microbiological and clinical monitoring of non-localized juvenile periodontitis in young adults: a report of 11 cases
Evidence of an association between functional abnormalities and defective diacylglycerol kinase activity in peripheral blood neutrophils from patients with localized juvenile periodontitis
Priming response to inflammatory mediators in hyperreactive peripheral neutrophils from adult periodontitis
Normal cell surface expression and selective loss of functions resulting from Phe110 to Ser and Cys126 to Trp substitutions in the formyl peptide receptor
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family
Neutrophil function in localized juvenile periodontitis. Phagocytosis, superoxide production and specific granule release
Immunoglobulins in periodontal tissues. II. Concentrations of immunoglobulins in granulation tissue from pockets of periodontosis and periodontitis patients
Clinical, laboratory, and immunological studies of a family with a high prevalence of generalized prepubertal and juvenile periodontitis
Neutrophil modulation by Actinobacillus actinomycetemcomitans. I. Chemotaxis, surface receptor expression and F-actin polymerization
Superoxide formation and chemiluminescence of peripheral polymorphonuclear leukocytes in rapidly progressive periodontitis patients
Influence of plasma components on luminol-enhanced chemiluminescence from peripheral granulocytes in juvenile periodontitis
In vivo crevicular leucocyte response in humans to a chemotactic challenge. Effects of periodontal diseases
Comparison of scanning and transmission electron microscopy of the epithelial pocket wall in juvenile and adult periodontitis
Peripheral PMN cells in juvenile periodontitis. Increased release of elastase and of oxygen radicals after stimulation with opsonized bacteria
Periodical gingival bleeding as a presenting symptom of periodontitis due to underlying cyclic neutropenia. Case report
Single nucleotide polymorphisms of the N-formyl peptide receptor in localized juvenile periodontitis
Increased respiratory burst activity is associated with normal expression of IgG-Fc-receptors and complement receptors in peripheral neutrophils from patients with juvenile periodontitis
A potential role of an intracellular signaling defect in neutrophil functional abnormalities and promotion of tissue damage in patients with localized juvenile periodontitis
Estimation of pentraxin-3 levels in the gingival tissues of chronic and aggressive periodontitis participants: an in vivo study
The association between inflammatory bowel disease and periodontitis among Jordanians: a case-control study
Chemotactic response of neutrophil polymorphonuclear leukocytes in juvenile periodontitis measured by the Leading Front method
Phagocytic cells in periodontal defense. Periodontal status of patients with chronic granulomatous disease of childhood
Effect of periodontal therapy on spontaneous lymphocyte response and neutrophil chemotaxis in localized and generalized juvenile periodontitis patients
Levamisole induced enhancement of polymorphonuclear leukocyte migration in patients with periodontitis
Refractory periodontitis associated with abnormal polymorphonuclear leukocyte phagocytosis and cigarette smoking
Immunologic profile of juvenile periodontitis. II. Neutrophil chemotaxis, phagocytosis and spore germination
Increased adhesion of peripheral blood neutrophils from patients with localized juvenile periodontitis
Serum neutralizing activity against Actinobacillus actinomycetemcomitans leukotoxin in juvenile periodontitis
Direct interaction of Actinobacillus actinomycetemcomitans with normal and defective (LJP) neutrophils
Monoclonal antibodies to lipopolysaccharide of four oral bacteria associated with periodontal disease
Polyamines found in gingival fluid inhibit chemotaxis by human polymorphonuclear leukocytes in vitro
Humoral immune response to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in periodontal disease
V101L of human formyl peptide receptor 1 (FPR1) increases receptor affinity and augments the antagonism mediated by cyclosporins
Clinical studies of one family manifesting rapidly progressive, juvenile and prepubertal periodontitis
Protracted necrotizing pharyngitis associated with an acquired defect of neutrophil chemotaxis in multiple myeloma
Antibodies directed to the chemotactic factor receptor detect differences between chemotactically normal and defective neutrophils from LJP patients
Comparison of neutrophil chemotactic response in diabetic patients with mild and severe periodontal disease
Paleopathology in Australopithecus africanus: a suggested case of a 3-million-year-old prepubertal periodontitis
Juvenile periodontitis as a model for neutrophil function: reduced binding of the complement chemotactic fragment, C5a
The autologous mixed lymphocyte reaction (AMLR) as a possible indicator of immunoregulation in chronic inflammatory periodontal disease
Increased oxidative product formation by peripheral blood polymorphonuclear leukocytes in human periodontal diseases
Refractory periodontitis: mixed infection with Bacteroides gingivalis and other unusual Bacteroides species. A case report
Clinical, microbiological and immunological studies of a family with a high prevalence of early-onset periodontitis
Generalized juvenile periodontitis, defective neutrophil chemotaxis and Bacteroides gingivalis in a 13-year-old female. A case report
Leukotoxicity of an extract from Actinobacillus actinomycetemcomitans for human gingival polymorphonuclear leukocytes
What exactly distinguishes aggressive from chronic periodontitis: is it mainly a difference in the degree of bacterial invasiveness?
Neutrophil defects and host-parasite interactions in the pathogenesis of localized juvenile periodontitis
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Genetic Screens in iPSC-derived Brain Cells
Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.
Alzheimer's Disease: MS4A
Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.
Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.
Pharmacology of Proteinopathies
This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.
This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.
Alignment-free Sequence Analysis Tools
Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.