Defective phosphatidylinositol 3-kinase signaling in central control of cardiovascular effects in the nucleus tractus solitarii of spontaneously hypertensive rats

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Michael HsiaoChing-Jiunn Tseng

Abstract

Recently we have shown functional involvement of the phosphatidylinositol 3-kinase (PI3K)-Akt-nitric oxide synthase (NOS) signaling pathway in central control of cardiovascular effects in the nucleus tractus solitarii (NTS) of normotensive Wistar-Kyoto (WKY) rats. In this study we determined whether PI3K/Akt signaling was defective in spontaneously hypertensive rats (SHR). WKY rats and SHR were anesthetized with urethane. Mean blood pressure (MBP) and heart rate (HR) were monitored intra-arterially. Unilateral microinjection (60 nL) of insulin (100 IU/mL) into the NTS produced prominent depressor and bradycardic effects in 8- and 16-week-old normotensive WKY and 8-week-old SHR. However, no significant cardiovascular effects were found in 16-week-old SHR after insulin injection. Furthermore, pretreatment with PI3K inhibitor LY294002 and NOS inhibitor L-NAME into the NTS attenuated the cardiovascular response evoked by insulin in WKY and 8-week-old SHR but not in 16-week-old SHR. Unilateral microinjection of 1 mmol/L of PI(3,4,5)P(3) (phosphatidylinositol 3,4,5-triphosphate), a phospholipids second messenger produced by PI3K, into the NTS produced prominent depressor and bradycardic effects in 8- or 16-week-old WKY rats as well a...Continue Reading

References

Dec 4, 1989·Brain Research·R AvidorI Gozes
Jul 1, 1997·Clinical and Experimental Hypertension : CHE·B J Morris
Jun 2, 1998·American Journal of Hypertension·T MakrisM Kyriakidis
Feb 17, 2000·The Journal of Clinical Investigation·K CusiL J Mandarino
Jul 30, 2002·The Journal of Biological Chemistry·John B J KwokVimal Kapoor
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Markus SchubertJens C Brüning
Sep 3, 2004·The Journal of Clinical Investigation·Kamal RahmouniWilliam G Haynes
Mar 29, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Maria A PotenzaMonica Montagnani
Sep 16, 2005·Journal of Human Hypertension·L TylickiW H Hörl
Mar 28, 2006·The Journal of Pharmacology and Experimental Therapeutics·Wan-Chen LoChing-Jiunn Tseng

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Citations

Sep 4, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hisae YoshitomiYukio Yamori
May 10, 2021·Exercise and Sport Sciences Reviews·Masaki MizunoScott A Smith

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