PMID: 6413552Oct 1, 1983Paper

Defective platelet aggregation to the calcium ionophore A23187 in a patient with a lifelong bleeding disorder

Journal of Clinical Pathology
S J MachinB A McVerry

Abstract

A patient with a lifelong bleeding disorder is presented with a prolonged bleeding time and abnormal aggregation and secretion responses to arachidonic acid, thromboxane A2, PAF-acether and the divalent calcium ionophore A23187. Platelet alpha and dense granule contents and morphology appear normal. The proposed defect is due to an abnormality of a platelet intracellular calcium dependent process.

References

Jun 1, 1977·European Journal of Biochemistry·H E Claesson, C Malmsten
Mar 1, 1979·British Journal of Haematology·N H RussellA J Bellingham
Jun 1, 1981·The Journal of Clinical Investigation·K K WuY C Chen
Nov 1, 1980·British Journal of Haematology·M ChignardJ Benveniste
Jul 1, 1982·British Journal of Haematology·M OkumaH Uchino
Jun 1, 1981·British Journal of Haematology·M SamamaM Dechavanne
Apr 1, 1980·Thrombosis Research·G C White, S T Raynor

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Citations

Jul 1, 1989·Baillière's Clinical Haematology·R M Hardisty
Oct 1, 1994·The Journal of Clinical Investigation·T HirataS Narumiya
Jan 1, 1996·Critical Reviews in Oncology/hematology·I Fuse

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