Defective platelet autocrine signaling in HPS.

Blood
Brian Storrie

Abstract

In this issue of Blood, Meng et al and Sharda et al use the Hermansky-Pudlak syndrome (HPS) as a model to show that adenosine 5′-diphosphate (ADP) released by dense granules serves as an autocrine signal to potentiate platelet release of α-granule and lysosome cargo and protein disulfide isomerase (PDI), all of which serve to stabilize thrombus formation.

References

Sep 13, 2003·Chest·Lawrence F Brass
Jun 2, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Wei LiRichard T Swank
Jun 29, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·A T NurdenU Seligsohn
Jun 4, 2013·Current Opinion in Cell Biology·Michael S MarksGraça Raposo
Jul 16, 2014·Current Opinion in Hematology·Timothy J StalkerLawrence F Brass

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