PMID: 6990882Feb 1, 1980Paper

Defective polymorphonuclear leucocyte chemotaxis in rheumatoid arthritis associated with a serum inhibitor

Annals of the Rheumatic Diseases
S M HanlonR Laurent

Abstract

Cellular and/or serum components of polymorphonuclear leucocyte chemotaxis were assessed in 21 patients with rheumatoid arthritis. No difference in the chemotactic migration of control and patient cells in response to a number of chemotactic solutions could be detected (P = 0.38). Deficient generation of chemotactic activity in patient sera (P = 0.58) as compared to control sera (P = 0.014) after incubation of the sera with Escherichia coli lipopolysaccharide, resulted in a significant difference in the chemotactic activity of the control and rheumatoid serum preparations for polymorphonuclear leucocytes (P = 0.0012). This defect was associated with the presence of a serum inhibitor of chemotaxis, the potency of which was inversely correlated with the level of chemotactic activity generated in the rheumatoid sera (r = -0.941, P less than 0.001).

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Citations

Mar 1, 1991·Arthritis and Rheumatism·A K JonesE C Huskisson
Jan 1, 1989·Archives of Dermatological Research·B GuillotJ J Guilhou
Aug 1, 1981·Annals of the Rheumatic Diseases·G B HoweH L Currey
Apr 1, 1984·Annals of the Rheumatic Diseases·D H GoddardE J Holborow
Jan 1, 1982·Scandinavian Journal of Rheumatology·S SpisaniS Traniello
Dec 6, 2001·The Pediatric Infectious Disease Journal·K D Yang, H R Hill
Sep 1, 1983·Arthritis and Rheumatism·B R AndersenJ P Niebel
Oct 1, 1987·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·T HerlinE Bunger
Apr 21, 2020·Database : the Journal of Biological Databases and Curation·Vidisha SinghAnna Niarakis
Dec 1, 1987·Disease-a-month : DM·L A Boxer, M L Morganroth

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