Defective polymorphonuclear neutrophil function in dairy cows showing enhanced susceptibility to intramammary infections

Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B
R Cooray, L Håkansson

Abstract

Polymorphonuclear-neutrophil (PMN) oxidative-burst activity, chemotactic and chemokinetic migratory responses, and surface-adhesion protein expression in a mastitis-prone group of dairy cows were compared with corresponding variables in healthy cows. The cows had a well-documented history of udder infection caused by major mastitis pathogens. Analysis of PMN functions revealed a deficiency in the luminol-enhanced chemiluminescence responses that seemed to be associated with the mobilization of myeloperoxidase (MPO) in the PMN of the patient group, as compared with the healthy controls. The migratory capacity of the PMN in response to a variety of chemotactic substances was enhanced in the patients. However, there were no significant differences between the two groups in the expression of surface-adhesion proteins (CD11a/CD18). It is proposed that the migratory activity of PMN cells was enhanced in order to compensate for their depressed respiratory-burst activity. Studies are under way to assess whether the defective mobilization of MPO in PMN of mastitis-prone cows is an acquired transient defect or a permanent hereditary defect.

References

Oct 11, 1992·Proceedings of the National Academy of Sciences of the United States of America·D E ShusterR O Gilbert
Oct 1, 1985·Veterinary Immunology and Immunopathology·N Craven, M R Williams
May 1, 1971·Australian Veterinary Journal·E O Brookbanks
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Oct 1, 1995·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·R CoorayR Båge

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Citations

Mar 1, 1997·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·R CoorayG Aström
Aug 6, 2011·Veterinary Immunology and Immunopathology·P AlarcónR A Burgos
Feb 24, 2001·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·A BaldiV Dell'Orto
Mar 20, 2001·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·D RysánekM Toman
Dec 9, 2003·Journal of Veterinary Internal Medicine·Christopher K CebraBernadette V Stang

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