PMID: 2504671Sep 1, 1989Paper

Defective protein phosphorylation associated with hypofunctions in stroke-prone spontaneously hypertensive rat platelets

Hypertension
T TomitaK Umegaki

Abstract

The mechanism of platelet dysfunctions in stroke-prone spontaneously hypertensive rats (SHRSP) was investigated. Platelet aggregation was inversely correlated with blood pressure or heart weight/body weight ratios in various strains of spontaneously hypertensive rats (SHR), indicating genetic defects. Thrombin-induced 47 kDa protein phosphorylation was markedly reduced in platelets of SHRSP compared with that in Wistar-Kyoto (WKY) rat platelets, accompanying reduced aggregation and secretion, but in 20 kDa protein phosphorylation was unchanged. Ca2+ ionophore A23187-induced responses were also significantly decreased in SHRSP, and the degrees of the changes were greater than those by thrombin. However, 12-O-tetradecanoylphorbol 13-acetate-induced responses in SHRSP were similar to those in WKY rats, suggesting that protein kinase C activity and its substrate were normally present in SHRSP platelets. Phosphatidylinositol content in platelets of SHRSP was 20% less than that in WKY rat platelets, but the contents of other phospholipids, including phosphatidylinositol-4-monophosphate and phosphatidylinositol-4,5-bisphosphates, were unaltered. Thrombin-induced formation of diacylglycerols and phosphatidic acid did not differ from ea...Continue Reading

References

Apr 1, 1979·The Journal of Clinical Investigation·S Rittenhouse-Simmons
Sep 15, 1979·Analytical Biochemistry·D A KennerlyT J Sullivan
Feb 1, 1975·Analytical Biochemistry·H H Hess, J E Derr
Nov 1, 1985·Hypertension·P HametJ Tremblay
Dec 15, 1986·Biochemical and Biophysical Research Communications·K TakaoriT Takeda
Jan 1, 1974·Methods in Enzymology·N L Baenziger, P W Majerus
Oct 23, 1981·Biochimica Et Biophysica Acta·J JollesW H Gispen
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S E Rittenhouse
Apr 15, 1982·Archives of Biochemistry and Biophysics·S L HofmannP W Majerus
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C A RouzerJ M Manning

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Citations

Jan 1, 1995·Clinical and Experimental Pharmacology & Physiology. Supplement·M HamanoT Tomita
Jan 1, 1993·Clinical and Experimental Hypertension : CHE·Y TakiguchiM Nakashima

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