Defective regulation of L1 endogenous retroelements in primary Sjogren's syndrome and systemic lupus erythematosus: Role of methylating enzymes

Journal of Autoimmunity
Clio P MavraganiMary K Crow

Abstract

To investigate whether altered DNA methylation contributes to the inappropriate expression of LINE-1 (L1) retroelements in primary Sjogren's syndrome (SS) and systemic lupus erythematosus (SLE). Minor salivary glands (MSG) were obtained from 42 patients with primary SS [23 without adverse predictors for lymphoma development (SS-low risk), 7 SS-high risk and 12 complicated by B-cell lymphoma (SS-lymphoma)] and 17 sicca controls (SC). Additionally, kidney biopsy specimens and PBMCs were obtained from 23 and 73 lupus patients, respectively. Relative mRNA expression was quantified for full-length L1 transcripts, along with mediators of methylation. In an independent set of 44 MSG samples (11 SS-low risk, 10 SS-high risk, 15 SS-lymphoma and 8 SC), methylation levels of the L1 promoter were determined by bisulphite pyrosequencing. A strong positive correlation was demonstrated between L1 transcripts and gene products that mediate de novo and constitutive DNA methylation, DNA methyltransferase (DNMT)3B, DNMT1, and methyl CpG binding protein 2 (MeCP2), in both SS MSG and lupus renal tissues. A significant negative correlation was observed between expression of L1 and lymphoid-specific helicase (LSH, encoded by HELLS) in both SS MSG and...Continue Reading

References

Sep 1, 1968·Journal of Clinical Pathology·D M Chisholm, D K Mason
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Dec 22, 1999·Nucleic Acids Research·T TchénioT Heidmann
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·T M Geiman, K Muegge
Sep 27, 2000·Human Molecular Genetics·T H Bestor
Jan 5, 2002·Molecular and Cellular Biology·Gangning LiangPeter A Jones
May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
Dec 19, 2003·Arthritis Research & Therapy·Mary K Crow, Jay Wohlgemuth
Jan 30, 2004·Journal of the American Society of Nephrology : JASN·Jan J WeeningMichio Nagata
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohammad Abdus SalamHidenobu Senpuku
Nov 23, 2006·Nature Cell Biology·Rabindranath De La FuenteKathrin Muegge
Feb 20, 2007·Human Mutation·Daria V Babushok, Haig H Kazazian
Sep 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Muller FabbriCarlo M Croce
Mar 6, 2008·PloS One·Amr H SawalhaJohn B Harley
Mar 28, 2008·International Journal of Cancer. Journal International Du Cancer·Shuji OginoCharles S Fuchs
Apr 9, 2008·DNA Repair·Stephen L GasiorPrescott L Deininger
May 12, 2009·Mutation Research·Diego E Montoya-DurangoKenneth S Ramos
Mar 11, 2010·Annals of the Rheumatic Diseases·Beth L CobbAmr H Sawalha
Mar 11, 2010·Nucleic Acids Research·Victoria P BelancioPrescott Deininger
Jul 7, 2010·Cell·Christine R BeckJohn V Moran
Aug 3, 2010·Journal of Autoimmunity·Clio P Mavragani, Mary K Crow
Nov 12, 2010·The New England Journal of Medicine·Timothy J LeyRichard K Wilson
Nov 19, 2010·Nature·Alysson R MuotriFred H Gage
Mar 19, 2011·Leukemia·M J WalterT A Graubert
Mar 24, 2011·Nature Reviews. Molecular Cell Biology·Mikiko C SiomiAlexei A Aravin
Apr 2, 2011·Mechanisms of Ageing and Development·Jing NiuTanjun Tong
Dec 3, 2011·The Journal of Clinical Investigation·Ryan A HladyRene Opavsky
Oct 12, 2012·Journal of Clinical Immunology·Kenneth L WileyBeverly D Lyn-Cook
Feb 23, 2013·Frontiers in Microbiology·Atsushi Koito, Terumasa Ikeda
Apr 5, 2013·PLoS Genetics·Nemanja Rodić, Kathleen H Burns
Jun 12, 2013·The Journal of Biological Chemistry·Xiaoyu LiShan Cen
Feb 27, 2015·The Journal of Biological Chemistry·Qiujing YuSerge Y Fuchs
Sep 15, 2015·Nature Structural & Molecular Biology·Matthias HamdorfIrene M Pedersen
Feb 26, 2016·Science·Reyad A ElbarbaryLynne E Maquat

❮ Previous
Next ❯

Citations

Mar 6, 2018·Journal of Dental Research·J PapinskaU S Deshmukh
Oct 18, 2018·Annual Review of Pathology·Mary K CrowKyriakos A Kirou
Jun 6, 2019·Clinical Reviews in Allergy & Immunology·Amandine CharrasYves Renaudineau
May 30, 2019·Frontiers in Immunology·Tomas MustelinNatalia V Giltiay
Jan 24, 2019·Journal of Immunology Research·Jeremy Kiripolsky, Jill M Kramer
Dec 2, 2020·Journal of Clinical Medicine·Ioanna E StergiouMichael Voulgarelis
Dec 17, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Clio P MavraganiMary K Crow
Feb 6, 2021·Journal of Clinical Medicine·Erika Huijser, Marjan A Versnel
Mar 7, 2021·Journal of Clinical Medicine·Kennedy C Ukadike, Tomas Mustelin
Nov 28, 2020·Current Opinion in Immunology·Mariana PostalTimothy B Niewold
Apr 30, 2021·Nature Reviews. Rheumatology·Gwenny M VerstappenFrans G M Kroese
Jun 8, 2021·Expert Review of Clinical Immunology·Vassilis E PapadopoulosClio P Mavragani
Aug 7, 2021·Trends in Genetics : TIG·Karla Cervantes-GraciaRichard Chahwan
Dec 5, 2020·Panminerva Medica·Alessia AlunnoFrancesco Carubbi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Lymphoproliferative Syndrome

Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated apoptosis. Discover the latest research on ALPS here.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.