Defective secretion of Prostaglandin F2α during development of idiopathic persistent corpus luteum in mares

Domestic Animal Endocrinology
O J GintherV G Santos

Abstract

Five mares that developed idiopathic persistent corpus luteum (PCL) were compared with 5 mares with apparently normal interovulatory intervals (IOIs). Progesterone (P4) and a metabolite of prostaglandin F2α (PGFM) were assayed daily beginning on the day of ovulation (Day 0). Transition between the end of an initial progressive P4 increase and the beginning of a gradual decrease in P4 occurred on mean Day 6. The gradual decrease in P4 between Days 6 and 12 was less (approached significance, P < 0.06) in the PCL group than in the IOI group. The P4 concentration on Day 12 (before luteolysis in IOI group) was greater (P < 0.05) in the PCL group than in the IOI group. In a post hoc comparison, an interaction (P < 0.04) of group by day for Days 4 to 7 indicated that the end of the progressive increase in P4 was temporally associated with a transient increase in concentration of PGFM in IOI mares but not in PCL mares. Complete luteolysis (P4 < 1 ng/mL) occurred in the IOI mares on Days 13 to 15. Partial luteolysis (mean P4 decrease, 62%) occurred in 3 of the 5 PCL mares. Normalization to the day at the end of the most pronounced P4 decrease in the IOI mares and in the 3 PCL mares with partial luteolysis resulted in a day-by-group inte...Continue Reading

References

May 1, 1990·Equine Veterinary Journal·O J Ginther
Oct 1, 1974·Equine Veterinary Journal·G H StabenfeldtD P Neely
Oct 1, 1972·Prostaglandins·R H Douglas, O J Ginther
Aug 27, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·O J GintherR A Pierson
Nov 29, 2005·Animal Reproduction Science·O J GintherM A Beg
Feb 24, 2006·The Veterinary Journal·C W WeemsR D Randel
Apr 30, 2015·Theriogenology·V G SantosO J Ginther

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Citations

Feb 11, 2020·Frontiers in Veterinary Science·Carrie K VanceNancy W Shappell
Feb 19, 2021·Theriogenology·M M Rivera Del AlamoT Reilas

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