PMID: 2495270Apr 1, 1989Paper

Defects in motility and development of Myxococcus xanthus lipopolysaccharide mutants

Journal of Bacteriology
J M Fink, J F Zissler

Abstract

Five transposon Tn5 mutants of the procaryote Myxococcus xanthus had been shown previously to be defective in lipopolysaccharide biosynthesis (J. M. Fink,-M. Kalos, and J. F. Zissler, J. Bacteriol. 171:2033-2041, 1989). These mutants were studied for possible defects in gliding motility and multicellular development. Wild-type M. xanthus cells glide both as single cells and as groups of cells. We found that the Tn5 lipopolysaccharide O-antigen mutants were defective in single-cell motility but were unaltered in group motility. These mutant strains were slow to develop but eventually gave rise to normal, spore-filled fruiting bodies. We also had shown previously that 56 (ethyl methanesulfonate-induced and spontaneous) phage-resistant mutants were defective in lipopolysaccharide biosynthesis. We found that many of these lipopolysaccharide O-antigen mutants were defective in single-cell motility but were unaltered in group motility. These mutants also gave rise to normal, spore-filled fruiting bodies. We also studied several phage-resistant mutants which were lacking a side-chain carbohydrate on the lipopolysaccharide core. These mutants possessed both single-cell motility and group motility but were altered in the magnitude of gl...Continue Reading

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Citations

Jun 9, 2005·Nature Biotechnology·Balaji S SrinivasanRoy D Welch
Feb 24, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Christopher N Vassallo, Daniel Wall
Sep 9, 2000·FEMS Microbiology Reviews·W Dawid
Nov 10, 2009·FEMS Microbiology Reviews·Anna KonovalovaLotte Søgaard-Andersen
Jun 10, 2020·PLoS Biology·Salim T IslamEmilia M F Mauriello
Sep 8, 1999·Microbiology and Molecular Biology Reviews : MMBR·A M Spormann
Nov 1, 1990·Journal of Bacteriology·M Kalos, J F Zissler
Mar 1, 1990·Journal of Bacteriology·W GodchauxE R Leadbetter
Dec 1, 1990·Microbiological Reviews·L J Shimkets
Aug 30, 2021·Molecular Microbiology·Fares SaïdiSalim T Islam

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