Defects in the allocation of cells to the inner cell mass and trophectoderm of parthenogenetic mouse blastocysts

Reproduction, Fertility, and Development
B Mognetti, D Sakkas

Abstract

Diploid parthenogenetic mouse embryos (which possess two maternally-derived genomes) can develop only as far as the 25-somite stage when transferred in utero and exhibit a substantial reduction in trophoblast tissue. The loss of cultured parthenogenetic embryos during postimplantation indicates that a defect in cell lineage may be evident as early as the blastocyst stage. The possibility that a defect may already be reflected at the preimplantation stage was investigated by examining the allocation of cells to the trophectoderm (trophoblast progenitor cells) and the inner cell mass of haploid and diploid parthenogenetic mouse blastocysts. Utilizing a differential labelling technique for counting cells, diploid parthenogenetic blastocysts were found to have fewer inner cell mass cells and trophectoderm cells than their haploid counterparts and normal blastocysts. In addition, both haploid and diploid parthenogenetic blastocysts had a lower inner cell mass: trophectoderm ratio than normal blastocysts. Thus, the relatively poor development of the trophectoderm lineage at the postimplantation stage is not reflected by a reduction in its allotment of cells at its first appearance. Nevertheless, the findings indicate that parthenogen...Continue Reading

Citations

Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J P Renard, C Babinet
Dec 17, 2008·Biology of Reproduction·Yong ChengKeith E Latham
Aug 30, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yi-Hui Chen, John Yu
Apr 14, 2005·Theriogenology·Simone Cristina MéoJoaquim Mansano Garcia
Apr 26, 2011·Differentiation; Research in Biological Diversity·Katarzyna SzczepanskaMarek Maleszewski
Apr 18, 2001·Reproduction in Domestic Animals = Zuchthygiene·A Van SoomA de Kruif
Sep 18, 2007·Advances in Immunology·John G Monroe, Kenneth Dorshkind
Oct 17, 2003·Biology of Reproduction·Irina LagutinaCesare Galli

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