Defects in the prostaglandin-system--heredity, prevalence and vascular risk analysis

Prostaglandins, Leukotrienes, and Essential Fatty Acids
I VirgoliniH Sinzinger

Abstract

2180 healthy adults, 620 patients (90% with cardiovascular disease, 10% others), 143 newborns and 351 relatives of persons in whom any abnormality of the prostaglandin (PG)-system had been discovered were involved in the Viennese Initiative for Prostaglandin (VIP)-Screening from 1984 through May 1989. The defects discovered were either inborn or acquired ones and were either familial or non-familial. The highest number of defects (54.8% of the total) identified were associated with PGI2. They indicated a lack of the PGI2-synthesis stimulating plasma factor (PF)-activity (n = 17) and PGI2-stabilizing capacity in plasma (defect 'Vienna-Döbling', n = 4, 12.9% of total), absence of high-affinity PGI2-binding sites on platelet membranes and lack of response of platelets to PGI2 (defect 'Vienna-Hietzing', n = 2, 6.5% of total). Furthermore, a lack of cyclooxygenase (n = 2, 6.5% of total), 12-lipoxygenase (defect 'Vienna-Penzing', n = 3, 9.7% of total) and thromboxane synthetase (n = 3, 9.7% of total) activities were diagnosed. In newborn screening, the PF-absence amounted to 2.8% (4/143), the lack of PGI2-stabilizing capacity to 0.7% (1/143). In adults, the prevalence is difficult to assess. Nevertheless, our findings indicate a freq...Continue Reading

References

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Citations

Oct 1, 1996·Applied Biochemistry and Biotechnology·A T MevkhI A Pishkina
Jan 1, 1991·Experimental Pathology·H SinzingerJ O'Grady
Dec 14, 2011·Hematology·Michele P Lambert
Sep 24, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Rosemarie A ReiterHelmut Sinzinger

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