Defects in the prostaglandin system--what is known?

Prostaglandins, Leukotrienes, and Essential Fatty Acids
Rosemarie A ReiterHelmut Sinzinger

Abstract

The central role of prostaglandins as local mediators is well accepted. Molecular biology and in particular knock-out mice models teach us a lot on mechanisms and eventual biological consequences. Despite the broad basic knowledge available, human data on defects in the prostaglandin system are extremely rare. Why? Don't we search for them? Are they of clinical relevance? What is their prevalence, the outcome? How to treat, if possible? For this purpose we are planning a platform and databank to improve knowledge, pool information and allow exchange of probes. All interested people are invited to join.

References

Jul 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·I VirgoliniH Sinzinger
Jul 1, 1986·Chest·O C BurghuberK Silberbauer
Jan 1, 1996·British Journal of Haematology·N Matijevic-AleksicK K Wu
Nov 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H KritzH Sinzinger
Dec 3, 1998·The Journal of Clinical Investigation·D W ThomasT M Coffman
Jun 3, 1999·American Journal of Respiratory and Critical Care Medicine·R M TuderN F Voelkel
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·H HizakiA Ichikawa
Jun 17, 2000·Progress in Lipid Research·Y SugimotoA Ichikawa

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Citations

Sep 4, 2007·Cancer Metastasis Reviews·Man-Tzu WangDaotai Nie
Dec 13, 2006·Translational Research : the Journal of Laboratory and Clinical Medicine·Khong Bee KangHenryk Majewski

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