PMID: 7547715May 1, 1995Paper

Defects in the structure and expression of the genes for the T cell marker Rt6 in NZW and (NZB x NZW)F1 mice

International Immunology
F Koch-NolteH G Thiele

Abstract

Rt6 is a T cell-restricted GPI-anchored membrane protein and a member of the family of mono(ADP-ribosyl)transferases. One of the two murine Rt6 genes is deleted in NZW mice. This finding is reminiscent of the deletion of one of the TCR beta genes in the same mouse strain and it is an intriguing possibility that these gene deletions arose by a common genetic mechanism. The Rt6 locus retained by the NZW mouse (designated Rt6-1) is polymorphic among inbred strains of laboratory mice. The NZW mouse shows several strain-specific restriction fragment length variants in this Rt6 locus and five amino acid substitutions occur in the predicted native Rt6 polypeptide of the NZW mouse relative to the corresponding polypeptides of NZB and BALB/c mice. Whereas transcript levels of the two Rt6 genes appear to be normal in spleen and intestine of NZB mice, the corresponding tissues of NZW mice show reduced levels of transcripts from the Rt6 locus retained in this mouse strain. Moreover, reduced levels of Rt6 mRNA also occur in spleen and intestine of (NZB x NZW)F1 hybrid animals, indicating that F1 animals have inherited a dominant factor from the genetic background of the NZW mouse, resulting in low levels of Rt6 expression. It is conceivable...Continue Reading

Citations

Dec 1, 1996·Current Opinion in Immunology·T J Vyse, B L Kotzin
Jan 23, 1999·European Journal of Biochemistry·N HaraM Tsuchiya
Oct 9, 2002·Molecular and Cellular Biology·Wiebke OhlroggeFriedrich Koch-Nolte
Aug 26, 1999·American Journal of Respiratory Cell and Molecular Biology·E BalducciJ Moss
Feb 14, 1997·The Journal of Biological Chemistry·J MossA A Rossini
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Z X LiuG Dennert
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S AdriouchM Seman
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroki KawamuraGunther Dennert
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shiyuan HongGeorge R Dubyak

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