PMID: 6105757Jan 1, 1980Paper

Defects of the otoconial membranes in normal guinea pigs

Acta Oto-laryngologica
L G JohnssonP J Henry

Abstract

Otoconial membranes from a large number of normal albino and pigmented guinea pigs were examined by light microscopy. In more than 20% of the animals, microdissection revealed that the crystalline layer of the otoconial membrane was incomplete, leaving large areas of the underlying gelatinous layer uncovered by crystals. These defects were bilateral, more or less symmetrical, and invariably more extensive in the saccule than in the utricle. In two animals, huge single conglomerates of crystals were found on both the saccular and utricular maculae. None of the animals displayed abnormal behavior or posture and no obvious cause for the otoconial defects was found. The presence of a hereditary congenital condition is postulated. The high incidence of otoconial defects in guinea pigs makes them poorly suited for most investigations of experimentally induced pathology. Therefore, previous reports of otoconial pathology in guinea pigs should be viewed in the light of these findings.

References

Sep 1, 1978·Acta Oto-laryngologica·C G Wright, D G Hubbard
Jul 1, 1977·Acta Oto-laryngologica·Y Harada, Y Sugimoto
Apr 1, 1972·The Annals of Otology, Rhinology, and Laryngology·L G Johnsson, J E Hawkins
Jul 1, 1972·The Laryngoscope·L G Johnsson, J E Hawkins
Sep 22, 1967·Science·L G Johnsson, J E Hawkins
Jan 1, 1970·Practica Oto-rhino-laryngologica·B KellerhalsW Villiger
Jul 1, 1951·The Journal of Physiology·M F LYON

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Citations

Apr 1, 1983·Archives of Oto-rhino-laryngology·A Serra, I La Mantia
Jan 1, 1980·Archives of Oto-rhino-laryngology·J T ChouH Scherer
Nov 1, 1981·American Journal of Otolaryngology·L G JohnssonC G Wright
Mar 1, 1982·American Journal of Otolaryngology·L G JohnssonJ E Hawkins
Jul 23, 2014·PloS One·Leif Erik WaltherRüdiger Kniep
May 1, 1980·Acta Oto-laryngologica·L G JohnssonP J Henry
Mar 21, 1998·Acta Oto-laryngologica·H N SondagW J Oosterveld

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