Defensin expression in chronic pouchitis in patients with ulcerative colitis or familial adenomatous polyposis coli

World Journal of Gastroenterology : WJG
Karlheinz KiehneKarl-Heinz Herzig

Abstract

Pouchitis develops in ileoanal pouches in up to 50% of patients with ulcerative colitis during the first 10 years after pouch surgery while being rare in patients after proctocolectomy for familial adenomatous polyposis coli (FAP) syndrome. Defensins are major components of the innate immune system and play a significant role in gastrointestinal microbial homeostasis. Pouch defensin and cytokine expression were correlated with states of pouch inflammation to study their role in pouchitis. Patients with ulcerative colitis and FAP syndrome were stratified into groups with pouches after surgery, pouches without or with pouchitis. Biopsies from terminal ileum from a healthy intestine or from normal terminal ileum of patients with ulcerative colitis served as controls. mRNA from pouches and controls was analysed for defensin and cytokine expression. Expression of defensins was increased in all pouches immediately after surgery, compared to ileum of controls. Initially, pouches in ulcerative colitis revealed higher defensin expression than FAP pouches. Defensin expression declined in both patient groups and increased again slightly in pouchitis in patients with ulcerative colitis. FAP pouches without pouchitis had strong expression o...Continue Reading

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Citations

Aug 22, 2007·Scandinavian Journal of Gastroenterology·Karlheinz KiehneKarl-Heinz Herzig
Nov 2, 2007·Alimentary Pharmacology & Therapeutics·H M HamerR-J Brummer
Apr 8, 2009·Current Opinion in Gastroenterology·Hao Wu, Bo Shen
Mar 16, 2011·Journal of Digestive Diseases·Feng Hua PeiBao Rong Chi
Jul 7, 2011·The Journal of Infectious Diseases·W ErhartI Meinhold-Heerlein
Aug 12, 2014·World Journal of Gastroenterology : WJG·Imerio AngrimanIgnazio Castagliuolo
Apr 16, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·X H GaoB Shen
Oct 11, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Marco ScarpaImerio Angriman
Nov 18, 2014·Inflammatory Bowel Diseases·Darren N Seril, Bo Shen
Nov 12, 2009·The American Journal of Gastroenterology·Gøri PerminowJan Wehkamp
Sep 19, 2006·Biochemistry. Biokhimii︠a︡·E V TsvetkovaV N Kokryakov
Feb 26, 2021·Frontiers in Oncology·Jun YangHushan Zhang
Nov 17, 2009·Gastroenterology Clinics of North America·Hao Wu, Bo Shen
Dec 1, 2009·The Medical Clinics of North America·Hao Wu, Bo Shen

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