Deferasirox for managing iron overload in people with thalassaemia

The Cochrane Database of Systematic Reviews
Joerg J MeerpohlDirk Bassler

Abstract

Thalassemia is a hereditary anaemia due to ineffective erythropoiesis. In particular, people with thalassaemia major develop secondary iron overload resulting from regular red blood cell transfusion. Iron chelation therapy is needed to prevent long-term complications.Both deferoxamine and deferiprone have been found to be efficacious. However, a systematic review of the effectiveness and safety of the new oral chelator deferasirox in people with thalassaemia is needed. To assess the effectiveness and safety of oral deferasirox in people with thalassaemia and secondary iron overload. We searched the Cystic Fibrosis and Genetic Disorders Group's Haemoglobinopathies Trials Register. We also searched MEDLINE, EMBASE, EBMR, Biosis Previews, Web of Science, Derwent Drug File, XTOXLINE and three trial registries: www.controlled-trials.com; www.clinicaltrials.gov; www.who.int./ictrp/en/. Date of the most recent searches of these databases: 24 June 2010.Date of the most recent search of the Group's Haemoglobinopathies Trials Register: 03 November 2011. Randomised controlled trials comparing deferasirox with no therapy or placebo or with another iron chelating treatment. Two authors independently assessed risk of bias and extracted data....Continue Reading

Citations

Apr 12, 2016·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Jafar AbolhasaniJavad Hassanzadeh
Jul 23, 2014·Nature Reviews. Nephrology·Juan Daniel Díaz-GarcíaAlberto Ortiz
Aug 22, 2013·The Cochrane Database of Systematic Reviews·Sheila A FisherDavid J Roberts
Oct 12, 2019·International Ophthalmology·Samira HeydarianMehdi Khabazkhoob
Jan 17, 2013·Hematology·Vedat Uygun, Erdal Kurtoglu
Aug 16, 2017·The Cochrane Database of Systematic Reviews·Claudia BolligJoerg J Meerpohl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

The Cochrane Database of Systematic Reviews
Joerg J MeerpohlDirk Bassler
The Cochrane Database of Systematic Reviews
D J RobertsC Hyde
The Cochrane Database of Systematic Reviews
Sheila A FisherD J Roberts
© 2022 Meta ULC. All rights reserved