Deferasirox-induced cytogenetic responses

Environmental Toxicology and Pharmacology
Mehmet Arslan, Hasan Basri Ila

Abstract

Deferasirox (commercially formulated as Exjade(®)) is one of the effective iron chelators used in treatment of iron overload diseases. In this study the effect of this substance for chromosome aberration, sister chromatid exchange and mitotic index was studied by in vitro (by using human peripheral lymphocytes) and in vivo (by using rat) analysis. Deferasirox increased the sister chromatid exchange frequency in all tested concentrations and periods in vitro. Also, in the presence of metabolic activator, the substance led to a statistically significant increase in the sister chromatid exchange frequencies only at high concentration. While in in vitro analysis the substance significantly increased abnormal cell percentages in all concentrations, in in vivo study the substance increased chromosome aberrations only in two concentrations at 12h treatment. In the cultured lymphocytes, deferasirox showed cytotoxicity by significantly reducing proliferation index and mitotic index values. While in the presence of metabolic activation it did not affect the proliferation index frequency, it had a stimulant effect on the mitotic index frequency. Deferasirox reduced significantly the mitotic index value in the bone marrow cells especially ...Continue Reading

References

Nov 1, 1978·Mutation Research·M L MaceW Wray
Nov 1, 1992·Toxicology and Applied Pharmacology·T J StinsonM J Plewa
Sep 1, 1986·Mutation Research·T P CooganD A Barsotti
May 1, 1983·Mutation Research·D M Maron, B N Ames
Sep 1, 1994·The New England Journal of Medicine·G M BrittenhamJ W Harris
Jan 1, 1996·Free Radical Biology & Medicine·L ZhangA J Davison
Dec 2, 1998·International Journal of Cancer. Journal International Du Cancer·T SimonartJ R Boelaert
Dec 23, 1999·The New England Journal of Medicine·N C Andrews
Nov 6, 2002·Environmental Health Perspectives·César Paz-y-MiñoPaola E Leone
Jun 13, 2006·European Journal of Pharmacology·Karine Chantrel-GroussardGérard Lescoat
Jul 17, 2007·Virology·Zufan DebebeSergei Nekhai
Jul 28, 2013·Cytotechnology·Hasan Basri IlaMehmet Büyükleyla

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Citations

Jun 11, 2019·Oxidative Medicine and Cellular Longevity·Hamidreza BadeliIlaria Peluso

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