Deferoxamine can prevent pressure ulcers and accelerate healing in aged mice

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Clark A BonhamGeoffrey C Gurtner

Abstract

Chronic wounds are a significant medical and economic problem worldwide. Individuals over the age of 65 are particularly vulnerable to pressure ulcers and impaired wound healing. With this demographic growing rapidly, there is a need for effective treatments. We have previously demonstrated that defective hypoxia signaling through destabilization of the master hypoxia-inducible factor 1α (HIF-1α) underlies impairments in both aging and diabetic wound healing. To stabilize HIF-1α, we developed a transdermal delivery system of the Food and Drug Administration-approved small molecule deferoxamine (DFO) and found that transdermal DFO could both prevent and treat ulcers in diabetic mice. Here, we demonstrate that transdermal DFO can similarly prevent pressure ulcers and normalize aged wound healing. Enhanced wound healing by DFO is brought about by stabilization of HIF-1α and improvements in neovascularization. Transdermal DFO can be rapidly translated into the clinic and may represent a new approach to prevent and treat pressure ulcers in aged patients.

References

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Feb 19, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Xianjie ZhangGregg L Semenza
Dec 10, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Lisa GouldKenneth Schmader
Dec 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Dominik DuscherGeoffrey C Gurtner
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Citations

Mar 4, 2020·Advanced Healthcare Materials·Moyuan QuAli Khademhosseini
Oct 1, 2020·Open Biology·Holly N Wilkinson, Matthew J Hardman
Jan 30, 2020·Advances in Wound Care·Clark A BonhamGeoffrey C Gurtner
Jan 4, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Riki ToitaJeong-Hun Kang
Feb 5, 2021·International Journal of Pharmaceutics·Di Fan, Qiaojun Fang
Jun 3, 2021·Advances in Wound Care·Ruth TevlinDerrick C Wan
Oct 7, 2021·Journal of Cellular and Molecular Medicine·Christopher V LavinDerrick C Wan

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