PMID: 5891709Nov 1, 1965

Defibrination syndrome with defective thrombinfibrinogen reaction reversible by protamine

Journal of Clinical Pathology
A L Bloom, N Campbell

Abstract

A patient with the obstetric defibrination syndrome successfully treated with human fibrinogen is described. The blood not only contained low levels of fibrinogen capable of clotting but also contained an inhibitor of the thrombin-fibrinogen reaction. This was neutralized in vitro with protamine but it was not heparin. Neither abnormality was detected by a latex agglutination test for plasma fibrinogen. The use of this test does not therefore exclude the diagnosis of the defibrination syndrome.

Citations

Jul 1, 1966·Journal of Clinical Pathology·J T RobertsA L Bloom
Sep 1, 1972·Journal of Clinical Pathology·J I Brody
Jan 1, 1969·Postgraduate Medical Journal·G L Saha
May 21, 2014·History of Psychiatry·Christopher Harding

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Blood Coagulation Disorders
Blood Coagulation Tests
Gamma-Fibrinogen
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