PMID: 9184811May 1, 1997Paper

Defibrotide augments the anticandidial activity of NK cells

General Pharmacology
A TurhanTurgut Imir

Abstract

1. The mechanism of action of Defibrotide, a fibrinolytic agent on Natural Killer (NK) cell cytotoxicity, was investigated through verapamil, TMB-8 cells and pertussis toxin. 2. Defibrotide increased the activity against Candida albicans cells (anticandidial activity), and it is determined that the calcium channels have a role in this effect. 3. Blockage of calcium channels reduced the anticandidial effect by 39.2%. Pertussis toxin led to a 10.7% inhibition, whereas the application of TMB-8 resulted in the stimulation of anticandidial activity. 4. It is concluded that defibrotide is a potent activator of NK cells.

References

Feb 1, 1992·The Journal of Experimental Medicine·L ShiA H Greenberg
Jan 1, 1989·The Journal of Experimental Medicine·P Garcia-PeñarrubiaA D Bankhurst
Nov 1, 1994·General Pharmacology·G OztürkN M Bor

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