journal cover

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

Blood

Mar 15, 1996

W S AlexanderD Metcalf

PMID: 8630375

Abstract

Mice with a null mutation in the thrombopoietin (TPO) receptor c-Mpl were generated by gene targeting. c-mpl-deficient mice developed normally but were deficient in megakaryocytes and severely thrombocytopenic. The hematocrit and numbers of mature circulating leukocytes were normal in m...read more

Mentioned in this Paper

Thrombocytopenia
Colony-Forming Units, Hematopoietic
Spleen
Megakaryocytes
Proteins, Recombinant DNA
Bone Marrow
MPL wt Allele
Thrombopoietin Receptor
Chimera Organism
White Blood Cell Count Procedure
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Immune Maturation

Abnormal immune system maturation is influenced by microbial stimulation and is believed to be a driving force behind the increase in allergies among children. Discover the latest research on Immune Maturation here.

Myelodysplastic Syndromes

Myelodysplastic syndromes are cancers in which immature blood cells in the bone marrow do not mature to become healthy blood cells. Discover the latest research on this cancer here.

Lymphoid Organ Development

The precise localization and structure of lymphoid organ development allows for an orchestrated immune response to an array of potential pathogens. Discover the latest research on Lymphoid Organ Development here.

Spatial & Lineage Atlas of Bone Marrow Hematopoiesis

Mapping bone marrow hematopoiesis by combining transcriptomics and imaging techniques will facilitate the study of hematopoietic disease and the development of novel therapeutics. This feed includes new research on analysis of the bone marrow hematopoiesis by multiple approaches.

Related Papers

The Journal of Experimental Medicine

Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin

The Journal of Experimental MedicineFebruary 1, 1996
F J de SauvageM W Moore
© 2020 Meta ULC. All rights reserved

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

Blood

Mar 15, 1996

W S AlexanderD Metcalf

PMID: 8630375

DOI:

Abstract

Mice with a null mutation in the thrombopoietin (TPO) receptor c-Mpl were generated by gene targeting. c-mpl-deficient mice developed normally but were deficient in megakaryocytes and severely thrombocytopenic. The hematocrit and numbers of mature circulating leukocytes were normal in m...read more

Mentioned in this Paper

Thrombocytopenia
Colony-Forming Units, Hematopoietic
Spleen
Megakaryocytes
Proteins, Recombinant DNA
Bone Marrow
MPL wt Allele
Thrombopoietin Receptor
Chimera Organism
White Blood Cell Count Procedure

Similar Papers Found In These Feeds

Immune Maturation

Abnormal immune system maturation is influenced by microbial stimulation and is believed to be a driving force behind the increase in allergies among children. Discover the latest research on Immune Maturation here.

Myelodysplastic Syndromes

Myelodysplastic syndromes are cancers in which immature blood cells in the bone marrow do not mature to become healthy blood cells. Discover the latest research on this cancer here.

Related Papers

The Journal of Experimental Medicine

Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin

The Journal of Experimental MedicineFebruary 1, 1996
F J de SauvageM W Moore
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
/papers/deficiencies-in-progenitor-cells-of-multiple/8630375