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Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

Blood

Mar 15, 1996

Warren S. AlexanderDonald Metcalf

PMID: 8630375

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Abstract

Mice with a null mutation in the thrombopoietin (TPO) receptor c-Mpl were generated by gene targeting. c-mpl-deficient mice developed normally but were deficient in megakaryocytes and severely thrombocytopenic. The hematocrit and numbers of mature circulating leukocytes were normal in m...read more

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Mice, Inbred C57BL
Anatomical Maturation
Thrombopoietin Measurement
Entire Spleen
Megakaryocytes
Investigation of Megakaryocytes
Hematopoietic System
Colony-Forming Units Assay
Hematocrit Procedure
Mutation Abnormality
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  • Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

    Blood

    Mar 15, 1996

    Warren S. AlexanderDonald Metcalf

    PMID: 8630375

    DOI:

    Abstract

    Mice with a null mutation in the thrombopoietin (TPO) receptor c-Mpl were generated by gene targeting. c-mpl-deficient mice developed normally but were deficient in megakaryocytes and severely thrombocytopenic. The hematocrit and numbers of mature circulating leukocytes were normal in m...read more

    Mentioned in this Paper

    Mice, Inbred C57BL
    Anatomical Maturation
    Thrombopoietin Measurement
    Entire Spleen
    Megakaryocytes

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