Deficiency in IL-17-committed Vγ4(+) γδ T cells in a spontaneous Sox13-mutant CD45.1(+) congenic mouse substrain provides protection from dermatitis

Nature Immunology
Elizabeth E GrayJason G Cyster

Abstract

Interleukin 17 (IL-17)-committed γδ T cells (γδT17 cells) participate in many immune responses, but their developmental requirements and subset specific functions remain poorly understood. Here we report that a commonly used CD45.1(+) congenic C57BL/6 mouse substrain is characterized by selective deficiency in Vγ4(+) γδT17 cells. This trait was due to a spontaneous mutation in the gene encoding the transcription factor Sox13 that caused an intrinsic defect in development of those cells in the neonatal thymus. The γδT17 cells migrated from skin to lymph nodes at low rates. In a model of psoriasis-like dermatitis, the Vγ4(+) γδT17 cell subset expanded considerably in lymph nodes and homed to inflamed skin. Sox13-mutant mice were protected from psoriasis-like skin changes, which identified a role for Sox13-dependent γδT17 cells in this inflammatory condition.

References

Jan 1, 1991·Developmental Immunology·S L ZebedeeW C Raschke
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K ItoS Tonegawa
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·F W ShenE A Boyse
Dec 12, 2003·Nature Reviews. Immunology·Ulrich H von Andrian, Thorsten R Mempel
Jan 20, 2007·Journal of Leukocyte Biology·Ildiko Van RhijnAd P Koets
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kensuke ShibataYasunobu Yoshikai
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina L RoarkRebecca L O'Brien
Apr 30, 2008·The Journal of Experimental Medicine·Taras KreslavskyHarald von Boehmer
Jul 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jan KisielowKlaus Karjalainen
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michio TomuraOsami Kanagawa
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kensuke ShibataYasunobu Yoshikai
Feb 5, 2009·Nature Structural & Molecular Biology·Saverio Brogna, Jikai Wen
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leslie van der FitsErik Lubberts
Apr 23, 2009·European Journal of Immunology·Jillian E WohlerScott R Barnum
Aug 8, 2009·The Journal of Clinical Investigation·Michael N HedrickJoshua M Farber
Oct 16, 2009·European Journal of Immunology·Jan D HaasImmo Prinz
Jan 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeong-su DoBooki Min
Apr 7, 2010·The Journal of Clinical Investigation·John S ChoLloyd S Miller
Feb 23, 2011·The Journal of Experimental Medicine·Nital SumariaWolfgang Weninger
Feb 23, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qing YuJyoti Misra Sen
May 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth E GrayJason G Cyster
Aug 5, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ute LaggnerFrank O Nestle
Sep 22, 2011·PloS One·Jian MaZuoming Sun
Oct 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomotaka MabuchiSam T Hwang
Apr 5, 2012·Nature Immunology·Kavitha NarayanImmunological Genome Project Consortium
May 2, 2012·The Journal of Clinical Investigation·Stanislav PantelyushinBurkhard Becher
Jul 7, 2012·PloS One·April E PriceRichard M Locksley
Oct 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Marie-Laure MichelAdrian C Hayday
Oct 16, 2012·The Journal of Clinical Investigation·Luigi TortolaManfred Kopf
Dec 21, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shannon K BromleyAndrew D Luster
Apr 1, 2007·Journal of Leukocyte Biology·Ildiko Van RhijnAd P Koets

Citations

Mar 4, 2014·Current Dermatology Reports·Szun S TayWolfgang Weninger
Jan 7, 2014·Annual Review of Immunology·Yueh-hsiu ChienMarc Bonneville
Jul 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Sara L ColpittsLeo Lefrançois
Jun 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Francisco Ramírez-ValleJason G Cyster
Sep 4, 2015·European Journal of Immunology·Tom HartwigBurkhard Becher
Feb 12, 2014·Alcoholism, Clinical and Experimental Research·Corey P ParletAnnette J Schlueter
Feb 5, 2015·Cellular Immunology·Rebecca L O'Brien, Willi K Born
Mar 18, 2015·Immunology and Cell Biology·Sioh-Yang TanWolfgang Weninger
Feb 24, 2015·Frontiers in Immunology·Rushikesh S PatilShubhada V Chiplunkar
Jan 8, 2015·Frontiers in Immunology·Vasileios BekiarisCarl F Ware
May 15, 2016·Trends in Immunology·Sakeen W Kashem, Daniel H Kaplan
Aug 15, 2015·PloS One·Kristina NadrahJoão P Pereira
May 28, 2016·Nature Reviews. Immunology·Yasmine Belkaid, Samira Tamoutounour
Jun 1, 2016·Immunology and Cell Biology·Gabriela V PingetKylie E Webster
Jul 13, 2016·Proceedings of the National Academy of Sciences of the United States of America·Pablo A RomagnoliKamal M Khanna
May 8, 2014·Gastroenterology·Raghavendra RaoGeorge Miller
Sep 22, 2016·The Journal of Infectious Diseases·Tesshin MurakamiYasunobu Yoshikai
Feb 23, 2017·Annual Review of Immunology·Sakeen W KashemDaniel H Kaplan
Mar 14, 2017·Trends in Immunology·Miguel Muñoz-RuizBruno Silva-Santos
May 19, 2017·Nature Immunology·Pedro H PapottoBruno Silva-Santos
Feb 20, 2018·Immunology and Cell Biology·Shweta TikooWolfgang Weninger
Oct 17, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abdul Rashid Bin Mohammad MuzakiChristiane Ruedl
Jun 2, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takahito SaitoNaoko Nakano
Sep 1, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreas MuschaweckhThomas Korn
Feb 1, 2018·The Journal of Experimental Medicine·Vanessa K RidauraYasmine Belkaid
Dec 10, 2017·Nature Communications·Tracy S H InMichele K Anderson
Apr 25, 2014·Nature·Lorena Riol-BlancoUlrich H von Andrian
Jul 27, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anil Kumar JaiswalAbdel Rahim A Hamad
Aug 23, 2018·Immunology·Aoi Akitsu, Yoichiro Iwakura
Aug 29, 2018·Immunology and Cell Biology·Hazel C PoyntzElizabeth Forbes-Blom
Dec 16, 2018·Immunology·Nital SumariaDaniel J Pennington
Apr 1, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Marília G de-OliveiraJefferson Russo Victor
Apr 12, 2014·Nature Reviews. Immunology·Manolis PasparakisFrank O Nestle
May 31, 2019·The Journal of Experimental Medicine·Lisa A MielkeGabrielle T Belz
Jun 5, 2019·The Journal of Experimental Medicine·Brian J LaidlawJason G Cyster
Feb 28, 2020·The Journal of Experimental Medicine·Sarah C EdwardsKingston H G Mills
Feb 7, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oliver DienzJonathan E Boyson
Sep 12, 2019·Seminars in Immunopathology·Cuong Thach NguyenIannis E Adamopoulos
Aug 26, 2020·Immunological Reviews·Toshiyasu SuzukiSeth B Coffelt
Aug 28, 2020·Immunological Reviews·Mia Hamilton JeeCharlotte Menné Bonefeld
Feb 26, 2014·Annals of the Rheumatic Diseases·Iannis E AdamopoulosEdward P Bowman
Aug 10, 2013·European Journal of Immunology·Immo PrinzDaniel J Pennington
Mar 16, 2018·Frontiers in Immunology·Girak KimCheol-Heui Yun
Jun 6, 2018·Frontiers in Immunology·Youenn JouanChristophe Paget
Jun 4, 2019·Frontiers in Immunology·Ryoyo IkebuchiMichio Tomura
May 9, 2019·Life Science Alliance·Shinya HatanoYasunobu Yoshikai
Jan 23, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amanda S Woodward DavisMichael J Bevan
Jun 7, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasutomo ImaiSam T Hwang
Feb 4, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kensuke ShibataYasunobu Yoshikai
Mar 20, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joana Barros-MartinsKarine Serre
Aug 25, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Theresa M CorpuzKylie E Webster
Nov 20, 2018·Nature Communications·Xianwei WangZhigang Tian
May 16, 2019·Archivum Immunologiae Et Therapiae Experimentalis·Ludimila Souza SantosJefferson Russo Victor
May 14, 2020·F1000Research·Alejandra V Contreras, David L Wiest
Mar 11, 2020·Frontiers in Immunology·Barbara PoleseIrah L King
Jul 1, 2020·Proceedings of the National Academy of Sciences of the United States of America·Charlotte HurabielleYasmine Belkaid
Mar 26, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hayakazu SumidaTakao Shimizu
Jun 6, 2017·Nature Communications·Duncan R McKenzieShaun R McColl
May 8, 2018·Frontiers in Immunology·Duncan R McKenzieShaun R McColl
Jun 20, 2018·Frontiers in Immunology·Yashu LiWeifeng He
Mar 8, 2019·Scientific Reports·Szabina HorváthÁgnes Kemény
Jun 26, 2020·Nature Reviews. Immunology·Daniel G PellicciStuart P Berzins
Nov 22, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kepeng YanWei Xu
Jul 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasuhiro MaedaKenji Chiba
May 17, 2017·Proceedings of the National Academy of Sciences of the United States of America·Tommaso TorcellanTatyana Chtanova
Dec 5, 2017·The Journal of Clinical Investigation·Ryunosuke MuroHarumi Suzuki
Aug 10, 2018·Scientific Reports·Yu SawadaKenji Kabashima
Jun 14, 2019·Frontiers in Immunology·Henry R Hampton, Tatyana Chtanova
Feb 3, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wanhong DingRichard D Granstein
Feb 11, 2020·Frontiers in Immunology·Morgan E Parker, Maria Ciofani
Nov 17, 2020·Immunological Reviews·Gina J FialaBruno Silva-Santos
Feb 4, 2021·Cell Reports·Shawn P FahlDavid L Wiest
Mar 8, 2021·The Journal of Investigative Dermatology·Cecilia Bivik EdingCharlotta Enerbäck
May 28, 2019·Current Opinion in Immunology·Nicholas A SpidaleJoonsoo Kang
Apr 2, 2021·Frontiers in Immunology·Praxedis MartinGaby Palmer
Oct 16, 2020·Nature Reviews. Immunology·Julie C RibotBruno Silva-Santos
Oct 16, 2020·Immunological Reviews·Michele K Anderson, Johanna S Selvaratnam
Dec 2, 2020·The Journal of Allergy and Clinical Immunology·Raquel Castillo-GonzálezFrancisco Sánchez-Madrid

Methods Mentioned

BETA
exome sequencing
PCR

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

The Journal of Clinical Investigation
Stanislav PantelyushinBurkhard Becher
The Journal of Immunology : Official Journal of the American Association of Immunologists
Jianlei HaoZhinan Yin
The Journal of Immunology : Official Journal of the American Association of Immunologists
Alison G MurphyRachel M McLoughlin
© 2021 Meta ULC. All rights reserved