Deficiency of Atg6 impairs beneficial effect of metformin on intestinal stem cell aging in Drosophila

Biochemical and Biophysical Research Communications
Hyun-Jin NaMi-Ae Yoo

Abstract

Age-related changes of adult stem cell are crucial for tissue aging and age-related diseases. Thus, clarifying mechanisms to prevent adult stem cell aging is indispensable for healthy aging. Metformin, a drug for type 2 diabetes, has been highlighted for its anti-aging and anti-cancer effect. In Drosophila intestinal stem cell (ISC), we previously reported the inhibitory effect of metformin on age-related phenotypes of ISC. Here, we showed that knockdown of Atg6, a crucial autophagy-related factor, in ISC induces age-related phenotypes of ISC such as hyperproliferation, centrosome amplification, and DNA damage accumulation. Then, we revealed that metformin inhibits ISC aging phenotypes in Atg6-dependent manner. Taken together, our study suggests that Atg6 is required for the inhibitory effect of metformin on ISC aging, providing an intervention mechanism of metformin on adult stem cell aging.

Citations

Jan 25, 2019·Biomolecular Concepts·Olivia HillsonCharalampos Rallis
Apr 26, 2019·Journal of Cellular Physiology·Yanping WuWeifen Li
Jan 29, 2021·World Journal of Stem Cells·Lin-Li Jiang, Lei Liu
Apr 26, 2020·Cell Metabolism·Ameya S KulkarniNir Barzilai
Apr 29, 2021·Autophagy·Elisabeth G FoersterDana J Philpott
Apr 6, 2021·Aging and Disease·Die HuTianyu Zhong
Aug 28, 2021·Annual Review of Pharmacology and Toxicology·Sri Nitya Reddy InduriXin Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.