PMID: 6406549May 1, 1983Paper

Deficiency of carbonic anhydrase in the vasculature of rabbit kidneys

The Journal of Clinical Investigation
R M Effros, S Nioka

Abstract

The transit of 14CO2 and H14CO3- through the renal vasculature was studied in rabbit kidneys perfused without erythrocytes and in an in vivo preparation in which erythrocytes were present. In the absence of erythrocytes, the transit of 14CO2 from the renal artery to renal vein was much more rapid than that of H14CO3-. This suggests that (a) there is insufficient carbonic anhydrase (c.a.) in the vasculature between the renal artery and the exchange vessels of the kidney to ensure equilibration between CO2 and HCO3- and (b) CO2 can diffuse directly between arterial and venous vessels in the kidney. Following infusions of carbonic anhydrase, the renal venous outflow patterns of 14CO2 and H14CO3- became the same in the perfused kidneys. Although the initial recovery of 14CO2 remained greater than that of H14CO3- after infusions of acetazolamide (a c.a. inhibitor), arteriovenous diffusion of 14CO2 was diminished by this agent. This is attributed to inhibition of renal tubular c.a. The outflow patterns of H14CO3- and 14CO2 were nearly the same in the presence of erythrocytes, indicating that erythrocyte c.a. is sufficiently accessible to permit virtual equilibration of these radionuclides during the interval required for transit betw...Continue Reading

References

Sep 1, 1978·The Journal of Clinical Investigation·E D Crandall, J E O'Brasky
Apr 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S S SpicerR E Tashian
May 1, 1975·The Journal of Clinical Investigation·R M EffrosT J Regan
May 9, 1977·Biochemical and Biophysical Research Communications·M K KoesterE A Noltmann
Apr 1, 1971·Acta Physiologica Scandinavica·G Lönnerholm
Aug 1, 1973·Acta Physiologica Scandinavica·G Lönnerholm
Jan 1, 1972·The Histochemical Journal·S Rosen
Feb 1, 1968·Circulation Research·W Perl, F P Chinard
Nov 1, 1969·The Journal of Clinical Investigation·R M Effros, F P Chinard
Aug 1, 1971·The International Journal of Applied Radiation and Isotopes·G D Hodgen, R J Falk
Feb 1, 1967·Circulation Research·K Aukland
Feb 1, 1980·Acta Physiologica Scandinavica·G Lönnerholm
May 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G Lönnerholm
Feb 1, 1980·Kidney International·G Lönnerholm, Y Ridderstråle

❮ Previous
Next ❯

Citations

Jan 1, 1987·Annals of Biomedical Engineering·R M EffrosJ Edwards
Oct 1, 1983·The Journal of Clinical Investigation·D A Maddox, F J Gennari
Jan 1, 1984·Annals of the New York Academy of Sciences·R M EffrosK Taki
Oct 1, 1984·Circulation Research·R M EffrosP Silverman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.