Deficiency of colonic telomerase in ulcerative colitis

The American Journal of Gastroenterology
B UsselmannC U Nwokolo

Abstract

GI epithelial cells express telomerase, a ribonucleoprotein that prevents telomeric shortening in proliferating cells. Telomerase levels are high in cancer, but little is known about telomerase expression in other diseases. We, therefore, designed experiments to determine telomerase expression in different colonic segments and to compare this with corresponding segments in patients with ulcerative colitis. Colorectal cancers and adenomatous polyps were included as disease controls. In total, telomerase expression was determined in colonic tissues obtained from 62 patients. Twenty-five patients had ulcerative colitis, 21 had normal colons, 11 had colorectal cancer, and nine had adenomatous polyps. Endoscopic biopsies were collected prospectively at colonoscopy, processed for telomerase assays (Telomeric Repeat Amplification Protocol), hematoxylin and eosin staining, and scored for inflammation. Telomerase activity is expressed in arbitrary units (median 95% confidence interval). In the normal colon, telomerase activity in the cecum, transverse, sigmoid, and rectum was 255 (171-449), 707 (374-895), 561 (468-1426), and 563 (402-846), respectively. Telomerase was higher in the distal three segments when compared with the cecum (p =...Continue Reading

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Citations

Dec 17, 2009·The New England Journal of Medicine·Rodrigo T Calado, Neal S Young
Feb 1, 2005·Alimentary Pharmacology & Therapeutics·K M GetliffeC U Nwokolo
Jul 30, 2011·World Journal of Gastroenterology : WJG·Ferenc SiposZsolt Tulassay
Mar 29, 2014·International Journal of Molecular Medicine·Mariann Friis-OttessenOle Petter F Clausen
Sep 22, 2005·Journal of Gastroenterology and Hepatology·Seung-Jae MyungYoung Il Min
Nov 20, 2013·Inflammatory Bowel Diseases·Gopabandhu Jena, Priyanka P Trivedi
Feb 19, 2002·Oncogene·Calvin B Harley
Jun 9, 2006·Current Opinion in Gastroenterology·Rosa Ana RisquesTeresa A Brentnall
Jan 6, 2006·European Journal of Gastroenterology & Hepatology·Katherine M GetliffeChuka U Nwokolo
Jul 16, 2021·Journal of Autoimmunity·Anne-Charlotte HebaNdeye Coumba Ndiaye

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