Jan 1, 1978

Deficiency of factor XII-dependent plasminogen proactivator in prekallikrein-deficient plasma

The Journal of Laboratory and Clinical Medicine
B N Bouma, J H Griffin

Abstract

Normal human plasma contains a factor XII (Hageman factor)-dependent plasminogen proactivator in its gamma globulin fraction. On the basis of both fibrin plate and clot lysis assays, this plasminogen proactivator activity was shown to be absent from the gamma globulin fraction of prekallikrein (Fletcher factor)-deficient plasma of two unrelated patients. This observation suggests that factor XII-dependent plasminogen proactivator is identical to plasma prekallikrein.

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Mentioned in this Paper

Plasma Prokallikrein A
Extrinsic Plasminogen Activators
Blood Coagulation Disorders
Prekallikrein Deficiency
Gamma globulin
KLKB1
Factor XII
Blood Coagulation Tests
Padutin

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