Jan 1, 1978

Deficiency of factor XII-dependent plasminogen proactivator in prekallikrein-deficient plasma

The Journal of Laboratory and Clinical Medicine
B N Bouma, J H Griffin


Normal human plasma contains a factor XII (Hageman factor)-dependent plasminogen proactivator in its gamma globulin fraction. On the basis of both fibrin plate and clot lysis assays, this plasminogen proactivator activity was shown to be absent from the gamma globulin fraction of prekallikrein (Fletcher factor)-deficient plasma of two unrelated patients. This observation suggests that factor XII-dependent plasminogen proactivator is identical to plasma prekallikrein.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Plasma Prokallikrein A
Extrinsic Plasminogen Activators
Blood Coagulation Disorders
Prekallikrein Deficiency
Gamma globulin
Factor XII
Blood Coagulation Tests

About this Paper

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.