Deficiency of heat shock transcription factor 1 suppresses heat stress-associated increase in slow soleus muscle mass of mice

Acta Physiologica
Yoshitaka OhnoKatsumasa Goto

Abstract

Effects of heat shock transcription factor 1 (HSF1) deficiency on heat stress-associated increase in slow soleus muscle mass of mice were investigated. Both HSF1-null and wild-type mice were randomly assigned to control and heat-stressed groups. Mice in heat-stressed group were exposed to heat stress (41 °C for 60 min) in an incubator without anaesthesia. Significant increase in wet and dry weights, and protein content of soleus muscle in wild-type mice was observed seven days after the application of the heat stress. However, heat stress had no impact on soleus muscle mass in HSF1-null mice. Neither type of mice exhibited much effect of heat stress on HSF mRNA expression (HSF1, HSF2 and HSF4). On the other hand, heat stress upregulated heat shock proteins (HSPs) at the mRNA (HSP72) and protein (HSP72 and HSP110) levels in wild-type mice, but not in HSF1-null mice. The population of Pax7-positive nuclei relative to total myonuclei of soleus muscle in wild-type mice was significantly increased by heat stress, but not in HSF1-null mice. Furthermore, the absence of HSF1 gene suppressed heat stress-associated phosphorylation of Akt and p70 S6 kinase (p-p70S6K) in soleus muscle. Heat stress-associated increase in skeletal muscle mas...Continue Reading

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Citations

Dec 17, 2015·Acta Physiologica·Pontus B Persson, Anna Zakrisson
Jun 5, 2019·Journal of Applied Physiology·Kyoungrae KimBruno T Roseguini
Dec 3, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S RacinaisJ D Périard
May 1, 2020·Journal of Applied Physiology·Kyoungrae KimBruno T Roseguini
Aug 9, 2020·Frontiers in Physiology·Mohammed IhsanSebastien Racinais

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