Deficiency of interleukin-1 receptor antagonist induces aortic valve disease in BALB/c mice

Arteriosclerosis, Thrombosis, and Vascular Biology
Kikuo IsodaFumitaka Ohsuzu

Abstract

Interleukin-1 receptor antagonist (IL-1Ra), one of the most important antiinflammatory cytokines, is crucial for homeostasis of the immune system. However, the role of IL-1Ra in aortic valve stenosis (AS) remains poorly understood [corrected]. IL-1Ra-deficient (IL-1Ra(-/-)) mice on the BALB/c background showed increased aortic valve leaflet thickness compared to wild-type mice at the age of 12 weeks (P<0.001). We used peripheral T-cell transplantation to examine the role of T cells in the development of AS. T cells from IL-1Ra(-/-) but not from wild-type mice induced increased aortic valve thickness in nu/nu mice. Moreover, IL-1Ra(-/-) T cells produced much higher levels of tumor necrosis factor (TNF)-alpha in culture supernatants after anti-CD3 antibody stimulation compared to wild-type mice (P<0.001). Finally, we studied the role of TNF-alpha in the development of AS in IL-1Ra(-/-) mice by generating double-gene-deficient (TNF-alpha(-/-)/IL-1Ra(-/-)) mice. Interestingly, TNF-alpha(-/-)/IL-1Ra(-/-) mice did not have AS. IL-1Ra deficiency in inflammatory cells induced aortic valve inflammation and TNF-alpha participates importantly in the development of AS in IL-1Ra(-/-) mice.

References

Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P F DaviesM A Gimbrone
Apr 1, 1993·Journal of the American College of Cardiology·M LindroosR Tilvis
Mar 1, 1997·Journal of the American College of Cardiology·B F StewartC M Otto
Jul 1, 1998·International Reviews of Immunology·C A Dinarello
Jun 7, 2000·The Journal of Clinical Investigation·A DaughertyL A Cassis
Jan 10, 2002·Journal of Cardiac Failure·K IsodaF Ohsuzu
Apr 12, 2002·Lancet·David M ShavelleKevin D O'Brien
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Madeleine W Cunningham
Apr 3, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Kikuo IsodaFumitaka Ohsuzu
Mar 23, 2005·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Jens J KadenMartin Borggrefe
Feb 6, 2007·Journal of the American College of Cardiology·Luis M MouraNalini M Rajamannan
Sep 22, 2007·Current Opinion in Lipidology·Satu HelskePetri T Kovanen
Oct 13, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Ziyad Al-AlyDwight A Towler

❮ Previous
Next ❯

Citations

May 28, 2011·Circulation Research·Jordan D MillerDonald D Heistad
Aug 10, 2011·International Journal of Inflammation·Krista L SiderCraig A Simmons
Jan 21, 2016·Expert Opinion on Therapeutic Targets·Lucie HénautAlberto Ortiz
Dec 10, 2015·Antioxidants & Redox Signaling·Joan Fernández EsmeratsHanjoong Jo
Jan 19, 2016·Global Cardiology Science & Practice·Alkistis KapelouzouDennis V Cokkinos
Jun 13, 2015·Journal of Immunology Research·Patrick MathieuMarie-Chloé Boulanger
Apr 16, 2015·Mediators of Inflammation·Xianli YuanMingcai Li
Dec 7, 2013·TheScientificWorldJournal·Antonella GaleoneGiacomina Brunetti
Nov 29, 2014·Current Allergy and Asthma Reports·Elise R Breed, Bryce A Binstadt
Mar 12, 2017·The Journal of Thoracic and Cardiovascular Surgery·Geng LiNianguo Dong
Jul 9, 2013·Circulation Research·Dwight A Towler
Nov 12, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Nicolle CeneriAlan R Morrison
Mar 12, 2019·Expert Opinion on Therapeutic Targets·Juliane Medler, Harald Wajant
May 18, 2016·Nature Reviews. Disease Primers·Brian R LindmanPhilippe Pibarot
May 27, 2014·Expert Review of Cardiovascular Therapy·Patrick MathieuRihab Bouchareb
Sep 13, 2019·Science Translational Medicine·Brian A AguadoKristi S Anseth
Jun 2, 2020·Frontiers in Pharmacology·Brunilda AlushiAlexander Lauten
Mar 30, 2018·Frontiers in Cardiovascular Medicine·Alexia HulinCécile Oury
Mar 19, 2019·Frontiers in Cardiovascular Medicine·Patrick Mathieu, Marie-Chloé Boulanger
May 6, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Michael A RaddatzW David Merryman
Jan 31, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Abigail HealyAlan R Morrison
Apr 17, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Michael A RaddatzW David Merryman
Mar 13, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Philip Roger GoodyFelix Jansen
Nov 25, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Arnaud ChignonPatrick Mathieu
Sep 18, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Joseph C GrimKristi S Anseth
Apr 22, 2021·Cardiovascular Research·Harry Z E GreenbergMin Zhang
Aug 26, 2021·Cardiovascular Research·Francesca Bartoli-LeonardElena Aikawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here