Deficiency of somatostatin (SST) receptor type 5 (SSTR5) is associated with sexually dimorphic changes in the expression of SST and SST receptors in brain and pancreas

Molecular and Cellular Endocrinology
José L RamírezU Kumar

Abstract

The actions of somatostatin (SST) are mediated through five somatostatin receptor subtypes, termed SSTR1-5. Although SSTRs commonly display an overlapping pattern of tissue distribution, subtype-selective responses have been shown to occur in the same tissue. In the present study, we have investigated the changes in SSTR subtypes at the cellular and molecular level in both the brain and the pancreatic islets of mice deficient in SSTR5 (SSTR5KO). Expression levels of insulin and glucagon were also determined in the pancreas of these mice. Semi-quantitative RT-PCR and Western blot analysis showed significant increases in the expression of SSTR2 and 3 with a corresponding reduction in SSTR4 in the brains of female SSTR5KOs, while no changes were observed in male KOs. Strikingly, SST mRNA and SST-like immunoreactivity (SST-LI) were reduced in the brain of male KO animals but not in their female counterparts. In male SSTR5KO islets, there was an increase in the number of cells immunoreactive for SSTR1-3, whereas in female islets only SSTR3 expression was increased. Pancreatic SST-LI and SST mRNA, as well as immunoreactivity for insulin were reduced in male but not in female KO mice. These data indicate that deficiency of SSTR5 leads...Continue Reading

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·W MeyerhofD Richter
Dec 15, 1983·The New England Journal of Medicine·S Reichlin
Jan 1, 1995·Life Sciences·Y C PatelC B Srikant
Nov 30, 1994·Biochemical and Biophysical Research Communications·W J Rossowski, D H Coy
May 1, 1996·Brain Research. Molecular Brain Research·R M SeñarísC Diéguez
Oct 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·V S ThossD Hoyer
Jun 1, 1997·Journal of Endocrinological Investigation·Y C Patel
Aug 8, 1998·The Journal of Surgical Research·S MoldovanF C Brunicardi
Feb 11, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S KhareA Y Patel
Aug 6, 1999·Frontiers in Neuroendocrinology·Y C Patel
Mar 14, 2000·The Journal of Biological Chemistry·M RochevilleY C Patel
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ramesh C PatelYogesh C Patel
May 29, 2002·Diabetes·Andrea HevenerJerrold Olefsky
Jul 30, 2002·Molecular Endocrinology·José L RamírezYogesh C Patel
Jan 4, 2003·Molecular Endocrinology·Mathias Z StrowskiHilary A Wilkinson

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Citations

Mar 8, 2006·Cancer Cell International·Heather L Watt, Ujendra Kumar
Jan 22, 2008·Molecular and Cellular Endocrinology·T Zeyda, U Hochgeschwender
May 12, 2009·Journal of Cellular and Molecular Medicine·Joeri Van Op den BoschJean-Pierre Timmermans
Jun 27, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J Van Op den BoschJ-P Timmermans
Feb 27, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J Van Op den BoschJ-P Timmermans
Apr 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mengxin WangTao Gong
May 31, 2014·International Journal of Neural Systems·Beata StrackKrzysztof J Cios

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