PMID: 6965452Jan 1, 1980Paper

Deficiency of T cell mediated regulation of anti-DNA production in systemic lupus erythematosus

Arthritis and Rheumatism
J D CloughL H Calabrese

Abstract

Isolated B cells from normal subjects and patients with systemic lupus erythematosus (SLE) could be stimulated to produce IgM anti-DNA with pokeweed mitogen. Normal but not SLE allogeneic T cells abrogated this response. Normal but not SLE autologous T cells promoted a switch from IgM to IgG anti-DNA production. SLE is characterized by at least two types of immunoregulatory abnormalities: a defect in T suppressor function and a defect in the IgM to IgG switchover.

References

May 10, 1979·The New England Journal of Medicine·E L ReinherzS F Schlossman
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T SakaneI Green
Jan 1, 1977·Journal of Immunological Methods·J D Clough
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Citations

Sep 1, 1981·Biulleten' eksperimental'noĭ biologii i meditsiny·E P MoskalenkoA M Poverennyĭ
Jun 1, 1980·Immunopharmacology·R S Krakauer, J D Clough
Mar 1, 1997·Bioorganic & Medicinal Chemistry·R M BillG D Glick
Jul 1, 1988·Immunological Investigations·Y Tomer, Y Shoenfeld
Feb 1, 1995·Seminars in Arthritis and Rheumatism·J E NashitzD Yeshurun
Jun 1, 1992·Clinical Biochemistry·S D Deodhar
Mar 1, 1985·Clinical Immunology and Immunopathology·R R ValleP H Schur
Jan 1, 1985·Arthritis and Rheumatism·J Alcocer-VarelaD Alarcón-Segovia
Feb 25, 1983·Journal of Immunological Methods·B J WeillP H Schur
May 1, 1990·Clinical Immunology and Immunopathology·M M WardD S Pisetsky

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