Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease.

Biochemical and Biophysical Research Communications
Stephanie J ChurchGarth J S Cooper

Abstract

Ob/ob mice provide an animal model for non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH) in patients with obesity and type-2 diabetes. Low liver copper has been linked to hepatic lipid build-up (steatosis) in animals with systemic copper deficiency caused by low-copper diets. However, hepatic copper status in patients with NAFLD or NASH is uncertain, and a validated animal model useful for the study of hepatic copper regulation in common forms of metabolic liver disease is lacking. Here, we report parallel measurements of essential metal levels in whole-liver tissue and defatted-dried liver tissue from ob/ob and non-obese control mice. Measurements in whole-liver tissue from ob/ob mice at an age when they have developed NAFLD/NASH, provide compelling evidence for factitious lowering of copper and all other essential metals by steatosis, and so cannot be used to study hepatic metal regulation in this model. By marked contrast, metal measurements in defatted-dried liver samples reveal that most essential metals were actually normal and indicate specific lowering of copper in ob/ob mice, consistent with hepatic copper deficiency. Thus ob/ob mice can provide a model useful for the study of copper regulati...Continue Reading

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Citations

Mar 9, 2017·IUBMB Life·Austin MorrellJason L Burkhead
Jun 28, 2017·Metallomics : Integrated Biometal Science·Jingshu XuGarth J S Cooper
Jun 26, 2017·Biochemical and Biophysical Research Communications·Xiang-Bo WeiQi-Qun Tang
Mar 9, 2018·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Jingshu XuGarth J S Cooper
Oct 18, 2018·Acta Cirúrgica Brasileira·Natalie Chaves CayuelaEdna Frasson de Souza Montero
Jun 1, 2019·Annual Review of Nutrition·Hannah PiersonSvetlana Lutsenko
Jan 30, 2020·Biological Trace Element Research·Sevginur AkdasNuray Yazihan
Dec 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Marie C HeffernChristopher J Chang
Feb 23, 2017·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Francesco BalestriAntonella Del-Corso
Jun 24, 2017·Journal of Pediatric Gastroenterology and Nutrition·Michael MendozaMiriam B Vos
Sep 21, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jack P GreenDavid Brough
Oct 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peter M MeggyesyMichael A Cater
Aug 9, 2021·Biochimica Et Biophysica Acta. General Subjects·Bryce BladesSharon La Fontaine

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