Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Antonia SerranoLoren H Parsons

Abstract

Negative emotional states that are associated with excessive alcohol intake, particularly anxiety-like states, have been linked to opponent processes in the central nucleus of the amygdala (CeA), affecting stress-related transmitters and monoamines. This study extends these observations to include endocannabinoid signaling in alcohol-dependent animals. Rats and mice were exposed to chronic intermittent alcohol with vapor inhalation or liquid diet to induce dependence. In vivo microdialysis was used to estimate interstitial concentrations of endocannabinoids [N-arachidonoylethanolamine (anandamide; AEA) and 2-arachidonoylglycerol (2-AG)] and amino acids (glutamate and GABA) in rat CeA. Additionally, we evaluated the inhibition of endocannabinoids clearance enzymes [monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase] on anxiety-like behavior and alcohol consumption in alcohol-dependent rats and mice. Results revealed that alcohol dependence produced decreases in baseline 2-AG dialysate levels and increases in baseline levels of glutamate and GABA. Acute alcohol abstinence induced an enhancement of these dependence-induced effects and the levels of 2-AG and GABA were restored upon alcohol re-exposure. Additional studies...Continue Reading

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Citations

Jan 10, 2019·Addiction Biology·David Roura-MartínezAlejandro Higuera-Matas
May 6, 2019·Addiction Biology·Carol A GianessiJane R Taylor
Jul 3, 2019·Alcoholism, Clinical and Experimental Research·Tammy Chung, R Adron Harris
Jul 3, 2019·British Journal of Pharmacology·Balapal S BasavarajappaShivakumar Subbanna
Sep 19, 2020·Alcoholism, Clinical and Experimental Research·Francisco J PavonAntonia Serrano
Oct 27, 2020·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Xiaomeng QiaoHongtao Yan
Jan 3, 2021·Reviews in Endocrine & Metabolic Disorders·Kwang-Mook JungDaniele Piomelli
Jan 29, 2021·The European Journal of Neuroscience·Carol A GianessiJane R Taylor
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Veronica M PiggottAlana C Conti
May 8, 2021·Frontiers in Psychiatry·Laurent ElkriefUNKNOWN IMAGEN consortium
May 15, 2021·Cannabis and Cannabinoid Research·Greta Niemela, Garth E Terry
Jun 12, 2021·Neuropharmacology·Gavin N PetrieMatthew N Hill
Nov 7, 2021·Neurotoxicity Research·Karen Jaqueline Paredes-RuizAna Laura Colín-González

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

Prism
GraphPad

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