Deficient habituation to repeated rectal distensions in irritable bowel syndrome patients with visceral hypersensitivity

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
M B O LowénS Walter

Abstract

Irritable bowel syndrome (IBS) patients show evidence of altered central processing of visceral signals. One of the proposed alterations in sensory processing is an altered engagement of endogenous pain modulation mechanisms. The aim was to test the hypothesis that IBS patients with (IBS-S) and without visceral hypersensitivity (IBS-N) differ in their ability to engage endogenous pain modulation mechanism during habituation to repeated visceral stimuli. Brain blood oxygen level dependent (BOLD) response was measured during repeated rectal distension and its anticipation in 33 IBS patients with and without visceral hypersensitivity and 18 healthy controls (HCs). BOLD response to early and late phase of the distension series was compared within and between groups. While BOLD response was similar during the early phase of the experiment, IBS-S showed greater BOLD response than IBS-N and HCs during the late phase of the distension series. IBS-S showed increasing BOLD response both to the anticipation and delivery of low intensity rectal distensions in brain regions including insula, anterior and mid cingulate cortex. IBS-N showed decreasing BOLD response to repeated rectal distensions in brain regions including insula, prefrontal c...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Jun 18, 1999·Science·A PloghausJ N Rawlins
May 30, 2002·Progress in Neurobiology·Mark J Millan
May 9, 2006·Gastroenterology·George F LongstrethRobin C Spiller
May 30, 2006·Arthritis and Rheumatism·Pedro MontoyaDolores Collado
Aug 7, 2007·Neuron·Irene Tracey, Patrick W Mantyh
Jan 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steven M BermanEmeran A Mayer
Jan 12, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Adeyemi LawalReza Shaker
May 27, 2008·Journal of Psychosomatic Research·Nora RappsQasim Aziz
Jun 17, 2008·British Journal of Anaesthesia·I Tracey
Jul 9, 2008·Trends in Cognitive Sciences·Katja WiechIrene Tracey
Aug 16, 2008·Neurobiology of Learning and Memory·Richard F Thompson
Dec 20, 2008·Nature Reviews. Neuroscience·A D Bud Craig
Jan 20, 2009·Brain Research Reviews·Julie A ChristiansonNathalie Vergnolle
Apr 4, 2009·Physiological Reviews·Jürgen Sandkühler
Aug 6, 2010·The Journal of Pain : Official Journal of the American Pain Society·Marina de TommasoPaolo Livrea
Nov 26, 2010·Annual Review of Medicine·Emeran A Mayer, Kirsten Tillisch
Nov 30, 2010·NeuroImage·Franco CaudaAlessandro Vercelli
Aug 1, 2013·The Journal of Headache and Pain·Gianluca CoppolaFrancesco Pierelli
Aug 9, 2013·The Cerebellum·Joswin KattoorSigrid Elsenbruch

❮ Previous
Next ❯

Citations

Dec 15, 2015·CNS Neuroscience & Therapeutics·Rachel D MoloneyJohn F Cryan
Jan 7, 2016·Frontiers in Behavioral Neuroscience·Sigrid Elsenbruch, Oliver T Wolf
Jun 18, 2015·Frontiers in Psychology·M Cornelia StoeckelAndreas von Leupoldt
Oct 25, 2016·European Journal of Pain : EJP·W ChoiC K Chung
Apr 6, 2007·Gastroenterology·Georg DimcevskiAsbjørn M Drewes
Dec 3, 2016·The Journal of Pain : Official Journal of the American Pain Society·C Richard Chapman, Charles J Vierck
Mar 4, 2017·Journal of Neurogastroenterology and Motility·In-Seon LeePaul Enck
Jan 16, 2018·F1000Research·Sigrid Elsenbruch, Paul Enck
Sep 27, 2018·Annals of the New York Academy of Sciences·Nathalie WeltensMichiko Kano
Nov 22, 2016·Journal of Neuroscience Research·Arpana GuptaLisa A Kilpatrick
Aug 21, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Susanne BeckerStefaan Van Damme
Dec 11, 2019·Annual Review of Clinical Psychology·Johan W S Vlaeyen, Geert Crombez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.