Deficient proactive interference of eyeblink conditioning in Wistar-Kyoto rats.

Behavioural Brain Research
Thomas M RicartRichard J Servatius

Abstract

Wistar-Kyoto (WKY) rats exhibit behavioral inhibition and model anxiety vulnerability. Although WKY rats exhibit faster active avoidance acquisition, simple associative learning or the influence of proactive interference (PI) has not been adequately assessed in this strain. Therefore, we assessed eyeblink conditioning and PI in WKY and outbred Sprague-Dawley (SD) rats. Rats were pre-exposed to either the experimental context, the conditioned stimulus (CS), the unconditional stimulus (US), or the CS & US in an explicitly unpaired (EUP) manner, to examine latent inhibition (LI), US pre-exposure effect, or learned irrelevance (LIRR), respectively. Immediately following pre-exposures, rats were trained in a delay-type paradigm (500 ms CS coterminating with a 10-ms US) for one session. During training SD rats exhibited LI and inhibition from US pre-exposures without evidence of LIRR. PI was less evident in WKY rats; LI was absent in WKY rats. Even in the context of reduced PI to CS-alone and US-alone pre-exposures, LIRR was not apparent in WKY rats. The more normal acquisition rates exhibited by WKY rats, under conditions which degrade performance in SD rats, increases the overall likelihood for WKY rats to acquire defensive respons...Continue Reading

References

May 1, 1969·Journal of Experimental Psychology·P Schnur, C J Ksir
Jun 1, 1969·Journal of Comparative and Physiological Psychology·S Siegel
May 1, 1995·The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology·C H BennettN J Mackintosh
Jan 1, 1993·Journal of Physiology, Paris·W P Paré, E Redei
Jul 1, 1993·Journal of the American Academy of Child and Adolescent Psychiatry·J BiedermanJ Kagan
Dec 20, 2000·Schizophrenia Research·H Braunstein-Bercovitz
May 9, 2001·Stress : the International Journal on the Biology of Stress·R J ServatiusJ E Ottenweller
Oct 2, 2001·The American Journal of Psychiatry·J BiedermanS V Faraone
Dec 1, 2001·Schizophrenia Research·H Braunstein-BercovitzR E Lubow
Nov 19, 2002·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·M Todd AllenGeoffrey Schnirman
Mar 8, 2003·The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology·Charlotte Bonardi, Siaw Yann Ong
Mar 8, 2003·The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology·A G BakerRick Mehta
Aug 6, 2003·Emotion·H Braunstein-BercovitzR E Lubow
Feb 1, 1956·Journal of Experimental Psychology·J A TAYLOR
Dec 6, 2003·Learning & Memory·Kimberly M Christian, Richard F Thompson
Mar 19, 2004·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Christopher J LoniganRebecca A Hazen
Apr 9, 2004·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·Kevin D Beck, Richard J Servatius
Feb 16, 2005·Annual Review of Psychology·Nathan A FoxMelissa M Ghera
Aug 11, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Xilu JiaoShanaz M Tejani-Butt
Aug 13, 2005·Biological Psychiatry·Oz MalkesmanAron Weller
Apr 20, 2006·Journal of Anxiety Disorders·Meredith E ColesAshley S Pietrefesa
Oct 2, 2007·Behavioural Brain Research·Jack D Shepard, Dean A Myers
May 16, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jaylyn WaddellTracey J Shors
May 27, 2008·Behavioural Brain Research·R J ServatiusT R Minor
Jun 3, 2009·Behavioral Neuroscience·Alexandra ThanellouJohn T Green

❮ Previous
Next ❯

Citations

Feb 24, 2016·Frontiers in Behavioral Neuroscience·Richard J Servatius
Jul 28, 2011·Stress : the International Journal on the Biology of Stress·Catherine E MyersRichard J Servatius
Oct 24, 2014·Frontiers in Behavioral Neuroscience·Pelin AvcuRichard J Servatius
Oct 18, 2014·Frontiers in Behavioral Neuroscience·Carina MosigArmin Zlomuzica
Nov 19, 2019·Behavioural Brain Research·Amanda M HaskellRichard J Servatius

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.