Deficient serum bactericidal activity against Escherichia coli in patients with cirrhosis of the liver

The Journal of Clinical Investigation
J Fierer, F Finley

Abstract

The serum bactericidal activity (SBA) of cirrhotic patients was compared with that of normal individuals using the release of (51)Cr from radiolabeled Escherichia coli as the assay method. 80% (22/27) of patients were found to have deficient SBA against at least one of three smooth, serum-sensitive test strains of E. coli. Cirrhotic patients were found to have normal levels of serum lysozyme. Although some patients were mildly hypocomplementemic, this abnormality did not correlate with the presence of a bactericidal defect. Bactericidal antibody in normal and cirrhotics' sera was limited to the immunoglobulin (Ig)M class. Purified IgM from patients with deficient SBA against E. coli 0111 had lower concentrations of bactericidal antibody for that E. coli than did IgM from normal sera; the calculated bactericidal activity of total serum IgM was also lower. The bactericidal defect in cirrhotic serum could be completely corrected by either human antiserum to the homologous strain of E. coli or by purified, normal human IgM. However, because higher concentrations of IgM were required to restore normal SBA to a cirrhotic's serum than to agammaglobulinemic serum, there may be an inhibitor of bactericidal antibody in addition to a defi...Continue Reading

References

Jan 1, 1977·Immunological Communications·J J LangoneT Borsos
Jul 1, 1973·The Journal of Infectious Diseases·A I BraudeC E Davis
Dec 1, 1973·The Journal of Clinical Investigation·E J ZieglerA I Braude
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Jun 1, 1969·The Journal of Experimental Medicine·I GoldschneiderM S Artenstein
Apr 6, 1972·The New England Journal of Medicine·A N DeMeo, B R Andersen
Feb 1, 1954·The Journal of Experimental Medicine·R DULBECCO, M VOGT
Mar 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·L H MUSCHEL

❮ Previous
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Citations

Jun 1, 1993·Journal of General Internal Medicine·P D King
Oct 1, 2010·Internal and Emergency Medicine·Mauro Bernardi
Apr 1, 1986·The Annals of Thoracic Surgery·W van OeverenC R Wildevuur
Jul 13, 2001·Infectious Disease Clinics of North America·D H Johnson, B A Cunha
Dec 29, 2000·Journal of Gastroenterology and Hepatology·R KirschR E Kirsch
Feb 7, 1985·The New England Journal of Medicine·J G Morris, R E Black
Jul 29, 2000·Journal of Clinical Gastroenterology·V CleophasG M Chandy
Apr 1, 1985·Gut·I R Crossley, R Williams
Sep 1, 1991·Gut·N Rolando, R J Wyke
Sep 1, 1982·Journal of Clinical Pathology·G HoldstockR Wright
Jan 1, 1989·Baillière's Clinical Gastroenterology·R J Wyke
Jul 30, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Hermann NeugebauerReiner Wiest
Feb 24, 2015·Alimentary Pharmacology & Therapeutics·C J KarvellasUNKNOWN Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group
May 5, 2004·Best Practice & Research. Clinical Gastroenterology·Guadalupe Garcia-Tsao, Reiner Wiest
May 28, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Alastair O'BrienDerek W Gilroy
Dec 17, 2014·The American Journal of Emergency Medicine·Chih-Chia HsiehWen-Chien Ko
Aug 2, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Naga S BetrapallyJasmohan S Bajaj
Dec 1, 1987·Scandinavian Journal of Gastroenterology·L LööfP Venge
Apr 15, 2014·Nature Medicine·Alastair J O'BrienDerek W Gilroy
Mar 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·X XiolL Casais
Mar 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I A Rajkovic, R Williams
Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P F BarnesT B Reynolds
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H OrregoI R Wanless
May 19, 2007·The American Journal of Gastroenterology·Leonidas ChristouMatthew E Falagas
Aug 28, 2018·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Do Seon Song
Feb 5, 2004·World Journal of Gastroenterology : WJG·Sebnem UstunGalip Ersoz
Dec 1, 1991·Liver·C H KuoY F Liaw
Nov 26, 2015·World Journal of Gastroenterology : WJG·Joshua HartmanAndrea D Branch
Sep 1, 1985·Infection and Immunity·M L TamplinH Friedman
Jun 11, 2021·Immunology Letters·Lazara Elena Santiesteban-LoresLorena Bavia

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