Deficit in specific cognitive domains associated with dementia in Parkinson's disease

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Anita PalRatna Sharma

Abstract

Impairment in different cognitive domains such as executive functions, language, memory and visuospatial skills occur frequently in Parkinson disease (PD) leading to significant disability and deterioration in quality of life. Heterogeneity of cognitive impairment enhances risk of developing dementia as disease progress. The objective is to explore the pattern of cognitive impairment with reference to the affected domains in PD with or without dementia relative to healthy controls. In this study, 110 PD patients and 26 healthy control were categorized into groups using Mini Mental State Examination and Clinical Dementia Rating scores as PD without dementia (PDND, n = 65; MMSE score >24; CDR = 0-1), PD with dementia (PDD, n = 45; MMSE score ≤24; CDR = 0.5-3) and healthy control (HC, n = 26; MMSE score >26; CDR = 0). Both Patients and controls underwent individual assessments of working memory, semantic memory, attention, language, executive functions, psychomotor and visuospatial skills and dementia using different cognitive function tests. Findings revealed lower scores of word memory, attention, psychomotor speed, visuospatial skills and executive functions in PDD compared to PDND. Interestingly, in PDD scores of picture memor...Continue Reading

Citations

Jun 11, 2019·Journal of Clinical and Experimental Neuropsychology·Krista SpecketerBrenna A Cholerton
Sep 12, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·María Teresa PeriñánPablo Mir
Sep 5, 2020·NPJ Parkinson's Disease·Thanaphong PhongpreechaThomas J Montine
Oct 7, 2020·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Ece BayramDeborah L Harrington
Oct 13, 2020·Journal of Alzheimer's Disease : JAD·Eman M KhedrAyman Gamea
Jan 16, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Gerardo Sánchez-DinorínRodolfo Solís-Vivanco
Apr 4, 2021·International Journal of Environmental Research and Public Health·Haewon Byeon
Aug 26, 2021·NPJ Parkinson's Disease·Thanaphong PhongpreechaThomas J Montine

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