Deficits in context-dependent adaptive coding in early psychosis and healthy individuals with schizotypal personality traits

Brain : a Journal of Neurology
Matthias KirschnerStefan Kaiser

Abstract

Adaptive coding of information is a fundamental principle of brain functioning. It allows for efficient representation over a large range of inputs and thereby alleviates the limited coding range of neurons. In the present study, we investigated for the first time potential alterations in context-dependent reward adaptation and its association with symptom dimensions in the schizophrenia spectrum. We studied 27 patients with first-episode psychosis, 26 individuals with schizotypal personality traits and 25 healthy controls. We used functional MRI in combination with a variant of the monetary incentive delay task and assessed adaptive reward coding in two reward conditions with different reward ranges. Compared to healthy controls, patients with first-episode psychosis and healthy individuals with schizotypal personality traits showed a deficit in increasing the blood oxygen level-dependent response slope in the right caudate for the low reward range compared to the high reward range. In other words, the two groups showed inefficient neural adaptation to the current reward context. In addition, we found impaired adaptive coding of reward in the caudate nucleus and putamen to be associated with total symptom severity across the s...Continue Reading

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Citations

Mar 17, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Matthias KirschnerAlain Dagher
Aug 23, 2021·Schizophrenia Bulletin·Ling-Ling WangRaymond C K Chan

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