Deficits in emotional learning and memory in an animal model of schizophrenia.

Behavioural Brain Research
Monica M BoltonJefferson W Kinney

Abstract

Alterations in N-methyl-D-aspartate (NMDA) receptor function have been linked to numerous behavioral deficits and neurochemical alterations. Recent investigations have begun to explore the role of NMDA receptor function on principally inhibitory neurons and their role in network function. One of the prevailing models of schizophrenia proposes a reduction in NMDA receptor function on inhibitory interneurons and the resulting disinhibition may give rise to aspects of the disorder. Studies using NMDA receptor antagonists such as PCP and ketamine have induced schizophrenia-like behavioral deficits in animal model systems as well as changes in inhibitory circuits. The current study investigated whether the administration of a subanesthetic dose of ketamine (8 mg/kg subcutaneously), that disrupts sensorimotor gating, also produces impairments in a Pavlovian emotional learning and memory task. We utilized both standard delay and trace cued and contextual fear conditioning (CCF) paradigms to examine if ketamine produces differential effects when the task is more difficult and relies on connectivity between specific brain regions. Rats administered ketamine displayed no significant deficits in cued or contextual fear following the delay...Continue Reading

References

May 1, 1992·Science·J J Kim, M S Fanselow
Oct 1, 1991·The American Journal of Psychiatry·D C Javitt, S R Zukin
Dec 6, 1991·Science·J W OlneyM A Sesma
Feb 12, 1990·Behavioural Brain Research·R J Sutherland, R J McDonald
Feb 1, 1990·Archives of General Psychiatry·D L Braff, M A Geyer
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Aug 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A C LahtiC A Tamminga
Dec 16, 1998·Schizophrenia Research·F SchneiderH W Müller-Gärtner
Sep 28, 1999·Trends in Pharmacological Sciences·F H MarshallB Bettler
May 10, 2000·Behavioural Brain Research·J C GewirtzM Davis
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Feb 27, 2001·Neurobiology of Learning and Memory·J W RyouH T Kim
Mar 13, 2001·Molecular Psychiatry·M Davis, P J Whalen
Dec 1, 2001·Neurobiology of Learning and Memory·A V BeylinT J Shors
Nov 27, 2002·The American Journal of Psychiatry·Raquel E GurRuben C Gur
Jun 6, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Axel BeckerGisela Grecksch
Mar 1, 1959·A.M.A. Archives of Neurology and Psychiatry·E D LUBYR KELLEY
Jul 1, 1962·The American Journal of Psychiatry·E D LUBYE F DOMINO
Apr 15, 2004·Current Opinion in Neurobiology·Elizabeth A Phelps
Jun 26, 2004·Annual Review of Neuroscience·James L McGaugh
Oct 22, 2004·Nature Reviews. Neuroscience·Stephen Maren, Gregory J Quirk
Nov 9, 2004·Schizophrenia Research·Keith H NuechterleinRobert K Heaton
Feb 5, 2005·Biological Psychiatry·E Fuller TorreyMichael B Knable
Apr 2, 2005·Nature Reviews. Neuroscience·David A LewisDavid W Volk

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Citations

Jan 22, 2013·ACS Chemical Neuroscience·James B Hanks, Javier González-Maeso
Sep 27, 2012·Neurobiology of Learning and Memory·Chelcie F HeaneyJefferson W Kinney
Dec 3, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Liran Hazan, Inna Gaisler-Salomon
Oct 16, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Monica M BoltonJefferson W Kinney
Sep 22, 2012·Ageing Research Reviews·Ginger Tsz-Hin WongAndrew Chi-Kin Law
Sep 15, 2012·Physiology & Behavior·Jonathan J SabbaghJefferson W Kinney
Sep 25, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sagnik BhattacharyyaPhilip McGuire
Aug 28, 2014·NeuroImage. Clinical·Pratik TalatiStephan Heckers
Jan 18, 2018·Journal of Psychopharmacology·Nicholas E CliftonJeremy Hall
Dec 3, 2016·Pharmacological Reports : PR·Joachim LatuszMarzena Maćkowiak
Oct 2, 2020·International Journal of Molecular Sciences·Kwang H ChoiKennett D Radford
Dec 18, 2020·Neurobiology of Learning and Memory·Maria MorenaPatrizia Campolongo
Mar 20, 2021·Behavioural Brain Research·Wiktor BileckiMarzena Maćkowiak
Apr 17, 2021·Neurochemistry International·Muhammad AsimXiaoguang Wang

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