Deficits in GABAA receptor function and working memory in non-smokers with schizophrenia

Schizophrenia Research
Alanna C BridgmanTony P George

Abstract

Although altered gamma-aminobutyric acid (GABA) neurotransmission has been implicated in the pathophysiology of schizophrenia, it is unclear whether the influence of GABA on working memory processes is confounded by nicotine use in this population. It is therefore crucial to evaluate working memory and its underlying mechanisms in non-smokers with schizophrenia to eliminate the confounding effects of nicotine on behavior and neurophysiology. In this cross-sectional study, working memory was assessed using the verbal N-back task, while GABAergic function was assessed through motor cortical inhibition using single and paired-pulse transcranial magnetic stimulation (TMS) to the left primary motor cortex in 11 non-smokers with schizophrenia and 13 non-smoker healthy subjects. Similar to previously published studies, working memory performance was significantly impaired in the 3-back condition in patients with schizophrenia compared to healthy subjects (p=0.036). In addition, GABAA receptor function was significantly reduced in schizophrenia as assessed by short interval cortical inhibition (SICI) (p=0.005). A positive correlation was found between GABAA inhibition and working memory performance on the 3-back task (r(23)=0.55, p=0.0...Continue Reading

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Citations

Nov 14, 2016·Neuroscience Bulletin·Dongsheng ZhouTi-Fei Yuan
Nov 15, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Hongyan RenTao Li
Jun 10, 2017·Frontiers in Human Neuroscience·Iseult A Cremen, Richard G Carson
Jun 18, 2020·Frontiers in Neuroscience·Aadith VittalaVaishnav Krishnan

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