Deficits in Glutamic Acid Decarboxylase 67 Immunoreactivity, Parvalbumin Interneurons, and Perineuronal Nets in the Inferior Colliculus of Subjects With Schizophrenia.

Schizophrenia Bulletin
Victor W KilonzoMatthew W Pitts

Abstract

Aberrant processing of auditory stimuli is a prominent feature of schizophrenia (SZ). Prior studies have chronicled histological abnormalities in the auditory cortex of SZ subjects, but whether deficits exist at upstream, subcortical levels has yet to be established. En route to the auditory cortex, ascending information is integrated in the inferior colliculus (IC), a highly gamma amino butyric acid (GABA) ergic midbrain structure that is critically involved in auditory processing. The IC contains a dense population of parvalbumin-immunoreactive interneurons (PVIs), a cell type characterized by increased metabolic demands and enhanced vulnerability to oxidative stress. During development, PVIs are preferentially surrounded by perineuronal nets (PNNs), specialized extracellular matrix structures that promote redox homeostasis and excitatory/inhibitory balance. Moreover, in SZ, deficits in PVIs, PNNs, and the GABA synthesizing enzyme, glutamic acid decarboxylase (Gad67), have been extensively documented in cortical regions. Yet, whether similar impairments exist in the IC is currently unknown. Thus, we compared IC samples of age- and sex-matched pairs of SZ and unaffected control subjects. SZ subjects exhibited lower levels of G...Continue Reading

References

Oct 1, 1978·Annals of Neurology·C KennedyL Sokoloff
Feb 1, 1990·Circulation Research·U GöbelW Kuschinsky
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M CavazzutiG C Barbieri
Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T M JayL Sokoloff
Jul 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·L LindstromK Bergstrom
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L Sokoloff
Sep 1, 1994·The Japanese Journal of Psychiatry and Neurology·M IgataK Abe
Apr 11, 1997·Schizophrenia Research·C L Beasley, G P Reynolds
Apr 4, 2000·Biological Psychiatry·A ParwaniJ P Rotrosen
Nov 14, 2000·Archives of General Psychiatry·S S ShergillP K McGuire
Sep 11, 2001·Psychopharmacology·M FendtJ S Yeomans
Feb 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jefferson W KinneyM Margarita Behrens
Jul 5, 2006·The European Journal of Neuroscience·Attila I GulyásHajime Hirase
May 1, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Manuel S MalmiercaEllen Covey
Oct 13, 2009·Behavioural Brain Research·Carlos Eduardo MacedoGuy Sandner
May 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elizabeth K LucasRita M Cowell
Apr 19, 2011·Comprehensive Psychiatry·Susanne M BauerThomas Stompe
Apr 6, 2012·PloS One·David Pérez-GonzálezManuel S Malmierca
May 11, 2012·Developmental Neuroscience·Neal R SwerdlowSusan B Powell
Dec 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel DuqueManuel S Malmierca
Jan 8, 2013·Frontiers in Neural Circuits·David Pérez-González, Manuel S Malmierca
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jan-Harry CabungcalKim Q Do
Jan 6, 2015·Neuropsychologia·Raffaele CacciagliaCésar Ávila
Aug 21, 2015·Nature Reviews. Neuroscience·Daniel C Javitt, Robert A Sweet
Nov 21, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew W PittsMarla J Berry
Feb 13, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John F EnwrightDavid A Lewis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.