PMID: 6409350May 5, 1983Paper

Deficits in locomotor behaviour and motor performance after central 6-hydroxydopamine or peripheral L-DOPA

Brain Research
G L WillisB McGrath

Abstract

Intracerebral injections of 6-hydroxydopamine (6-OHDA) which produce deficits in locomotor behaviour and motor performance cause localized accumulation of monoamines as well as depletion of central catecholamines (CA). To determine whether the localized increases in monoamines could be contributing to the behavioural deficits seen after intracerebral 6-OHDA injection, the behavioural and biochemical effects of peripherally administered L-DOPA were compared to those which occurred after central injections of 6-OHDA. Forty-five minutes after the injection of 40 mg/kg of L-DOPA, in animals pretreated with 50 mg/kg of R04-4602, the ability to step down, to retract a limb and to ambulate were significantly impaired. Locomotor behaviour and body temperature of L-DOPA-injected animals were similar to those displayed by animals receiving intracerebral injections of 6-OHDA. Fluorescent histochemical and biochemical assessment of diencephalic and telencephalic CA revealed that depletion of CA was not related to the severity of the motor deficits which occurred, but that increased diencephalic CA were present in impaired animals injected with either 6-OHDA or L-DOPA. These findings support the contention that increased CA in degenerating ...Continue Reading

References

Nov 1, 1977·Brain Research Bulletin·G Singer, G L Willis
Feb 1, 1979·Journal of Comparative and Physiological Psychology·J S Fink, G P Smith
May 1, 1974·Pharmacology, Biochemistry, and Behavior·G E Martin, R D Myers
Dec 1, 1971·Nature: New Biology·N J Uretsky, R I Schoenfeld
May 1, 1971·British Journal of Pharmacology·G R Breese, T D Traylor
Mar 1, 1980·Pharmacology, Biochemistry, and Behavior·G L Willis, G Singer

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Citations

Jun 1, 1985·Brain Research·G L Willis, G C Smith
Jul 1, 1987·Brain Research Bulletin·G L WillisG C Smith
Jan 1, 1996·Pediatric Neurology·N GrigoriadisO Guiba-Tziampiri
Jul 15, 1999·Physiology & Behavior·G L Willis, S M Armstrong
Sep 5, 1998·Brain Research. Brain Research Reviews·G L Willis, S M Armstrong
Dec 17, 1984·Brain Research·G L WillisB McGrath
Jan 1, 1987·Neuroscience and Biobehavioral Reviews·G L Willis
Jul 1, 1992·The International Journal of Neuroscience·G L WillisR Sandyk
Jul 1, 1992·The International Journal of Neuroscience·G L Willis, R Sandyk
Sep 1, 1992·The International Journal of Neuroscience·R Sandyk, G L Willis
Jul 21, 2017·Frontiers in Neurology·Gregory L Willis, Christopher B Freelance
Feb 17, 2006·Journal of Medicinal Chemistry·Antonio Di StefanoFrancesco Pinnen
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·L L Bernardis, L L Bellinger

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