Deficits in olfactory sensitivity in a mouse model of Parkinson's disease revealed by plethysmography of odor-evoked sniffing.

Scientific Reports
Michaela E JohnsonDaniel W Wesson

Abstract

Hyposmia is evident in over 90% of Parkinson's disease (PD) patients. A characteristic of PD is intraneuronal deposits composed in part of α-synuclein fibrils. Based on the analysis of post-mortem PD patients, Braak and colleagues suggested that early in the disease α-synuclein pathology is present in the dorsal motor nucleus of the vagus, as well as the olfactory bulb and anterior olfactory nucleus, and then later affects other interconnected brain regions. Here, we bilaterally injected α-synuclein preformed fibrils into the olfactory bulbs of wild type male and female mice. Six months after injection, the anterior olfactory nucleus and piriform cortex displayed a high α-synuclein pathology load. We evaluated olfactory perceptual function by monitoring odor-evoked sniffing behavior in a plethysmograph at one-, three- and six-months after injection. No overt impairments in the ability to engage in sniffing were evident in any group, suggesting preservation of the ability to coordinate respiration. At all-time points, females injected with fibrils exhibited reduced odor detection sensitivity, which was observed with the semi-automated plethysmography apparatus, but not a buried pellet test. In future studies, this sensitive meth...Continue Reading

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Citations

Sep 15, 2020·Journal of Parkinson's Disease·Aishwarya S KulkarniDaniel W Wesson
Feb 7, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Norihito UemuraRyosuke Takahashi
Jul 30, 2021·Ageing Research Reviews·Xiuli DanVilhelm A Bohr
Aug 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chao XieJeffrey R Martens
Sep 17, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Tarun N BhatiaRehana K Leak

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