PMID: 5921387Dec 2, 1966

Deficits in passive avoidance and fear conditioning in mice with septal lesions

Science
B M Slotnick, M E Jarvik

Abstract

By means of a simple activity measure, mice with lesions of the septal forebrain were tested for passive avoidance (response inhibition) and fear conditioning. In two separate experiments animals with septal lesions showed little or no conditioning, as evidenced by lack of suppression of activity during and following activitycontingent foot shock. Results support and extend thehypothesis that these deficits in passive avoidance derive from the removal of normal inhibitory influences mediated by the septal area.

Citations

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Related Concepts

Avoidance Learning
Brain
Structure of Interventricular Foramen
Conditioning (Psychology)
Operant Conditioning

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