PMID: 5921387Dec 2, 1966

Deficits in passive avoidance and fear conditioning in mice with septal lesions

B M Slotnick, M E Jarvik


By means of a simple activity measure, mice with lesions of the septal forebrain were tested for passive avoidance (response inhibition) and fear conditioning. In two separate experiments animals with septal lesions showed little or no conditioning, as evidenced by lack of suppression of activity during and following activitycontingent foot shock. Results support and extend thehypothesis that these deficits in passive avoidance derive from the removal of normal inhibitory influences mediated by the septal area.


Jan 1, 1972·Psychopharmacologia·A S Marriott, E F Smith
Sep 1, 1968·European Journal of Pharmacology·J R BoissierC Aron
May 1, 1967·International Journal of Neuropharmacology·Z Bohdanecký, M E Jarvik
Jul 1, 1971·Neuropharmacology·C AronJ R Boissier
Nov 1, 1970·Physiology & Behavior·B M Slotnick, D L Brown
Apr 1, 1972·Physiology & Behavior·S Greenstein, S D Glick
Jan 1, 1972·Physiology & Behavior·B M Slotnick
Feb 1, 1973·Physiology & Behavior·B M Slotnick, M F McMullen
May 1, 1978·Physiology & Behavior·W P Smotherman, S Levine
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·J A Gray, N McNaughton
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·J N Crawley
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·E S Onaivi, B R Martin
Mar 1, 1977·Brain Research Bulletin·J Henderson, E Greene
Jan 1, 1981·Progress in Neuro-psychopharmacology·H FrancèsP Simon
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·M HascoetA Couetoux du Tertre
May 15, 1969·Annals of the New York Academy of Sciences·J F LubarD G Wells
Jul 30, 1969·Annals of the New York Academy of Sciences·J R Boissier, P Simon
Jul 11, 2008·Critical Reviews in Toxicology·Edward J Calabrese
Nov 30, 2006·Journal of Pharmacological Sciences·Akiyoshi SaitohJunzo Kamei

Related Concepts

Avoidance Learning
Structure of Interventricular Foramen
Conditioning (Psychology)
Operant Conditioning

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