Deficits in preference-based health-related quality of life after complications associated with tibial fracture

The Bone & Joint Journal
I L GitajnG Slobogean

Abstract

The aims of this study were to quantify health state utility values (HSUVs) after a tibial fracture, investigate the effect of complications, to determine the trajectory in HSUVs that result in these differences and to quantify the quality-adjusted life years (QALYs) experienced by patients. This is an analysis of 2138 tibial fractures enrolled in the Fluid Lavage of Open Wounds (FLOW) and Study to Prospectively Evaluate Reamed Intramedullary Nails in Patients with Tibial Fractures (SPRINT) trials. Patients returned for follow-up at two and six weeks and three, six, nine and 12 months. Short-Form Six-Dimension (SF-6D) values were calculated and used to calculate QALYs. Compared with those who did not have a complication, those with a complication treated either nonoperatively or operatively had lower HSUVs at all times after two weeks. The HSUVs improved in all patients with the passage of time. However, they did not return to the remembered baseline preinjury values nor to US age-adjusted normal values by 12 months after the injury. While the acute fracture and complications may have resolved clinically, the detrimental effect on a patient's quality of life persists up to 12 months after the injury. Cite this article: Bone Joi...Continue Reading

References

Dec 1, 1991·Aktuelle Traumatologie·H Habernek, G Walch
Jul 6, 1996·BMJ : British Medical Journal·J Cairns
Apr 8, 1999·Injury·C M Court-BrownM M McQueen
Oct 3, 1999·The Journal of Bone and Joint Surgery. American Volume·M F SwiontkowskiJ Agel
Apr 10, 2002·Journal of Health Economics·John BrazierMark Deverill
May 10, 2003·Health and Quality of Life Outcomes·Stephen J Walters, John E Brazier
Aug 21, 2004·Medical Care·John E Brazier, Jennifer Roberts
Jul 4, 2006·Injury·Charles M Court-Brown, Ben Caesar
Feb 14, 2007·Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention·W L WatsonJ Richardson
Sep 11, 2007·Injury·M FergusonUNKNOWN Victorian Orthopaedic Trauma Outcomes Registry (VOTOR) Research Group
Sep 2, 2008·Journal of Orthopaedic Trauma·Kelly A LefaivrePiotr A Blachut
Dec 3, 2008·The Journal of Bone and Joint Surgery. American Volume·UNKNOWN Study to Prospectively Evaluate Reamed Intramedullary Nails in Patients with Tibial Fractures InvestigatorsStephen D Walter
Mar 11, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Paul KindDennis Raisch
Mar 11, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Milton C WeinsteinAlistair McGuire
Dec 27, 2011·Journal of Orthopaedic Trauma·Heather A VallierBrendan M Patterson
Jan 18, 2012·Health Economics·Bernard van den Berg
Jun 16, 2012·Health and Quality of Life Outcomes·Ross WilsonJohn Langley
May 1, 2013·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Benjamin M CraigJohn E Brazier
Sep 1, 2015·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Janel HanmerDennis G Fryback
Oct 9, 2015·The New England Journal of Medicine·UNKNOWN FLOW InvestigatorsGordon H Guyatt

❮ Previous
Next ❯

Citations

Jan 1, 2020·The Bone & Joint Journal·Ryan W TrickettIan Pallister
Jan 1, 2020·The Bone & Joint Journal·Sunny ParikhShanmuganathan Rajasekaran
May 3, 2020·The Journal of Bone and Joint Surgery. American Volume·Mohit BhandariTheodore Miclau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.