Deficits in water maze performance and oxidative stress in the hippocampus and striatum induced by extremely low frequency magnetic field exposure.

PloS One
Yonghua CuiYi Che

Abstract

The exposures to extremely low frequency magnetic field (ELF-MF) in our environment have dramatically increased. Epidemiological studies suggest that there is a possible association between ELF-MF exposure and increased risks of cardiovascular disease, cancers and neurodegenerative disorders. Animal studies show that ELF-MF exposure may interfere with the activity of brain cells, generate behavioral and cognitive disturbances, and produce deficits in attention, perception and spatial learning. Although, many research efforts have been focused on the interaction between ELF-MF exposure and the central nervous system, the mechanism of interaction is still unknown. In this study, we examined the effects of ELF-MF exposure on learning in mice using two water maze tasks and on some parameters indicative of oxidative stress in the hippocampus and striatum. We found that ELF-MF exposure (1 mT, 50 Hz) induced serious oxidative stress in the hippocampus and striatum and impaired hippocampal-dependent spatial learning and striatum-dependent habit learning. This study provides evidence for the association between the impairment of learning and the oxidative stress in hippocampus and striatum induced by ELF-MF exposure.

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Citations

Jan 8, 2013·Cell Biochemistry and Biophysics·Vesna SelakovićBranka Janać
Jan 15, 2015·International Journal of Radiation Biology·Dajana TodorovićAleksandar Kalauzi
May 20, 2016·Environmental Monitoring and Assessment·Mojgan GhadamgahiMonireh Hosseini
Apr 29, 2015·International Journal of Environmental Research and Public Health·Tin-Tin Win-ShweNaoki Kunugita
Jun 9, 2018·Environmental Science and Pollution Research International·Yaqian XuGuoqing Di
Oct 21, 2018·Scientific Reports·Qinhao LinGuoqing Di
Dec 12, 2018·Oxidative Medicine and Cellular Longevity·Silvano Junior SantiniGiovanna Di Emidio
Feb 26, 2014·Physiological Research·Y LiT Song
May 5, 2021·Annals of the New York Academy of Sciences·Federico BertagnaKamalan Jeevaratnam

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