Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome

Brain Research
M A KurtD C Davies

Abstract

Ts65Dn mice are partially trisomic for the distal region of MMU16, which is homologous with the obligate segment of HSA21 triplicated in Down syndrome (DS). Ts65Dn mice are impaired in learning tasks that require an intact hippocampus. In order to investigate the neural basis of these deficits in this mouse model of Down syndrome, quantitative light and electron microscopy were used to compare the volume densities of neurons and synapses in the hippocampus of adult Ts65Dn (n=4) and diploid mice (n=4). Neuron density was significantly lower in the CA1 of Ts65Dn compared to diploid mice (p<0.01). Total synapse density was significantly lower in the dentate gyrus (DG; p<0.001), CA3 (p<0.05) and CA1 (p<0.001) of Ts65Dn compared to diploid mice. The synapse-to-neuron ratio was significantly lower in the DG (p<0.001), CA3 (p<0.01) and CA1 (p<0.001) of Ts65Dn compared to diploid mice. When the data were broken down by synapse type, asymmetric synapse density was found to be significantly lower in the DG (p<0.001), CA3 (p<0.05) and CA1 (p<0.001) of Ts65Dn compared to diploid mice, while such a difference in symmetric synapse density was only present in the DG (p<0.01). The asymmetric synapse-to-neuron ratio was significantly lower in t...Continue Reading

References

Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P Corsi, J T Coyle
Jan 1, 1985·Annals of the New York Academy of Sciences·C J EpsteinL B Epstein
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y GeinismanF Morrell
May 1, 1984·Journal of Neuroscience Methods·R Morris
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Oct 1, 1995·Nature Genetics·R H ReevesM T Davisson
Oct 20, 1995·Neuroscience Letters·R M EscorihuelaJ Flórez
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·D M HoltzmanW C Mobley
Dec 1, 1996·Behavioural Brain Research·G E DemasP J Yarowsky
Dec 1, 1996·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·S T DeKoskyS D Styren
Jan 23, 1998·Brain Research. Brain Research Protocols·T MikiY Takeuchi
Apr 1, 1998·Behavioural Brain Research·G E DemasP J Yarowsky
Oct 29, 1998·Neuroscience Letters·A M InsaustiT F Vallina
Feb 7, 2001·Annual Review of Psychology·E T Rolls
Jul 16, 2003·The European Journal of Neuroscience·J L Bizon, M Gallagher
Jul 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael A PackerGrigori Enikolopov

❮ Previous
Next ❯

Citations

Dec 12, 2012·Apoptosis : an International Journal on Programmed Cell Death·Noemí RuedaCarmen Martínez-Cué
Oct 1, 2013·Trends in Neurosciences·Karen T ChangKyung-Tai Min
May 6, 2010·American Journal on Intellectual and Developmental Disabilities·Mohammed Rachidi, Carmela Lopes
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Katheleen GardinerMara Dierssen
Jul 19, 2011·Neural Plasticity·Laura BaroncelliAlessandro Sale
Jun 12, 2012·Neural Plasticity·Noemí RuedaCarmen Martínez-Cué
Jan 26, 2010·Progress in Neurobiology·Andrea ContestabileLaura Gasparini
Jun 15, 2007·Neuroscience Letters·Fabian Fernandez, Craig C Garner
Dec 18, 2007·Brain Research·Sonia PalminielloAdam A Golabek
Jan 31, 2012·Brain Research·Ananya MitraDaniel V Madison
May 21, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Devsmita DasAhmad Salehi
Aug 4, 2015·Nature Neuroscience·J WittonM W Jones
Dec 31, 2011·Biochimica Et Biophysica Acta·Ira T Lott
Jan 15, 2014·Neuroscience and Biobehavioral Reviews·Carmen Martínez-CuéMarie-Claude Potier
Jun 23, 2016·Journal of Neurochemistry·Katarzyna LepetaConstanze Seidenbecher
Aug 9, 2011·Reviews in the Neurosciences·Renata BartesaghiElisabetta Ciani
Sep 28, 2007·Neuroscience Research·Mohammed Rachidi, Carmela Lopes
Aug 22, 2018·Journal of Neural Engineering·L Nathan PerkinsTimothy J Gardner
Jan 26, 2018·Scientific Reports·Chia-Chu ChiangDominique M Durand
Oct 3, 2007·Mental Retardation and Developmental Disabilities Research Reviews·Ahmad SalehiWilliam C Mobley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.