Defining aggressive prostate cancer using a 12-gene model

Neoplasia : an International Journal for Oncology Research
Tarek A BismarM A Rubin

Abstract

The critical clinical question in prostate cancer research is: How do we develop means of distinguishing aggressive disease from indolent disease? Using a combination of proteomic and expression array data, we identified a set of 36 genes with concordant dysregulation of protein products that could be evaluated in situ by quantitative immunohistochemistry. Another five prostate cancer biomarkers were included using linear discriminant analysis, we determined that the optimal model used to predict prostate cancer progression consisted of 12 proteins. Using a separate patient population, transcriptional levels of the 12 genes encoding for these proteins predicted prostate-specific antigen failure in 79 men following surgery for clinically localized prostate cancer (P = .0015). This study demonstrates that cross-platform models can lead to predictive models with the possible advantage of being more robust through this selection process.

References

Oct 1, 1993·Genes, Chromosomes & Cancer·J A MacoskaS R Wolman
Sep 10, 1998·Journal of the National Cancer Institute·C Cordon-CardoH I Scher
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Dec 7, 2000·The American Journal of Pathology·S SignorettiM Loda
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Johannes V SwinnenGuido Verhoeven
Apr 3, 2002·JAMA : the Journal of the American Medical Association·Mark A RubinArul M Chinnaiyan
Jun 28, 2002·Cancer Cell·Dinesh SinghWilliam R Sellers
Jun 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edward P Gelmann
Oct 11, 2002·Nature·Sooryanarayana VaramballyArul M Chinnaiyan
Mar 22, 2003·Lancet·Angelo M DeMarzoJonathan I Epstein
Aug 30, 2003·The Journal of Biological Chemistry·Xiaomin Mu, Chawnshang Chang
Sep 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Celina G KleerArul M Chinnaiyan
Dec 23, 2003·Journal of Cellular Biochemistry·Antonella BaronMassimo Loda
Jan 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jacques LapointeJonathan R Pollack
Jan 20, 2004·Cancer Research·Daniel B MartinPeter S Nelson
Jan 31, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mark A Rubin, Angelo M De Marzo
Apr 7, 2004·The Journal of Clinical Investigation·Gennadi V GlinskyWilliam L Gerald
Apr 8, 2004·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
Jun 3, 2004·Cancer Research·Mark A RubinArul M Chinnaiyan

❮ Previous
Next ❯

Citations

Aug 11, 2007·World Journal of Urology·Eric Schiffer
Jun 24, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mark A Rubin
Jun 14, 2013·Omics : a Journal of Integrative Biology·Nadège RabiauDominique Bernard-Gallon
May 29, 2007·The American Journal of Surgical Pathology·Sven PernerMark A Rubin
Jun 28, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lorelei A MucciMark A Rubin
Jan 22, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Preet K DhillonLorelei A Mucci
Dec 19, 2013·PloS One·Christian R GomezStanimir Vuk-Pavlović
Apr 9, 2014·BMC Cancer·Anthony E RizzardiStephen C Schmechel
Jun 16, 2011·Journal of the American Medical Informatics Association : JAMIA·James L ChenYves A Lussier
Dec 18, 2009·Expert Review of Molecular Diagnostics·Karina Dalsgaard Sørensen, Torben Falck Ørntoft
Dec 26, 2012·Clinical Biochemistry·Elisa PinEmanuel F Petricoin
Dec 18, 2007·Neoplasia : an International Journal for Oncology Research·Fatouma AlimirahDivaker Choubey
Mar 27, 2007·The Journal of Pathology·J-M MosqueraM A Rubin
Apr 20, 2011·Cell Cycle·Nilesh D KashikarPran K Datta
Jul 15, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Ana CheongShuk-Mei Ho
Feb 17, 2015·Korean journal of urology·Yuri TolkachHendrik Van Poppel
Aug 27, 2013·Cell Cycle·Yuyan ChenJennifer A Byrne
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John C ChevilleGeorge Vasmatzis
Feb 27, 2008·Statistics in Medicine·Ronglai ShenJeremy M G Taylor
Apr 10, 2008·The Prostate·Christopher J ShepherdDavid L Hudson
May 28, 2013·International Journal of Molecular Sciences·Lien SpansFrank Claessens
Mar 8, 2018·Journal of Cancer Research and Clinical Oncology·Hatem Abou-OufTarek A Bismar
Jan 4, 2012·Histopathology·Glen Kristiansen
Jul 4, 2019·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Xue-Chao LiLi-Jun Chen
Dec 10, 2013·International Journal of Oncology·Pierre TennstedtRonald Simon
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mona ShehataJennifer A Byrne
Feb 21, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew D DarnelTarek A Bismar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.