Defining Failure of Medical Therapy for Inflammatory Bowel Disease

Inflammatory Bowel Diseases
Neil Volk, Corey A Siegel

Abstract

Over the past 2 decades, advances in biologic and small molecule therapeutics have resulted in a rapid increase in our armamentarium of therapies for inflammatory bowel disease. Despite these advancements, Crohn's disease and ulcerative colitis remain chronic and progressive diseases. One of the primary reasons for persistent inflammation and bowel damage is failure of medical therapy. With growing therapeutic options, there is an increased temptation to quickly move to the next therapy and label the prior therapy as a failure; however, this can lead to inadequate optimization of medications and poor control of disease. On the other hand, failure to recognize ongoing mucosal inflammation despite optimized treatment and moving to the next agent can lead to progression of disease and long-term complications. As our options for medical therapy continue to increase, it has become more important to recognize failure of therapy in order to promptly move to the next therapeutic agent without abandoning therapies prematurely. In this review, we aim to define failure of medical therapy for inflammatory bowel disease with the goal of offering guidance on when it is appropriate to attempt optimization of current medical treatment as oppos...Continue Reading

References

Aug 31, 1999·Clinical Nuclear Medicine·I SarikayaG Aras
Feb 24, 2001·Scandinavian Journal of Gastroenterology·J BelaicheE Louis
Jun 20, 2002·Diseases of the Colon and Rectum·Lisa S PoritzWalter A Koltun
Sep 25, 2004·Journal of Pharmaceutical Sciences·Evelyn D LoboJoseph P Balthasar
Aug 26, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Elana A MaserGordon R Greenberg
Jul 20, 2007·The New England Journal of Medicine·William J SandbornUNKNOWN PRECISE 1 Study Investigators
Sep 14, 2007·Scandinavian Journal of Gastroenterology·Trine OlsenJon Florholmen
Nov 22, 2007·Journal of Pediatric Gastroenterology and Nutrition·Ulrika Lorentzon FagerbergYigael Finkel
Sep 12, 2008·Clinical Pharmacology and Therapeutics·W WangJ P Balthasar
Sep 26, 2008·Inflammatory Bowel Diseases·L Hancock, N J Mortensen
Sep 17, 2009·European Journal of Clinical Pharmacology·Adedigbo A FasanmadeHonghui Zhou
Apr 28, 2010·International Journal of Clinical Pharmacology and Therapeutics·A A FasanmadeH M Davis
Jun 30, 2010·Annals of Surgery·Douglas W Jones, Samuel R G Finlayson
Nov 12, 2010·Annals of the Rheumatic Diseases·Anna JamnitskiGerrit Jan Wolbink
May 26, 2011·Gut·Guillaume Bouguen, Laurent Peyrin-Biroulet
Jun 19, 2013·Gastroenterology·William J SandbornUNKNOWN PURSUIT-Maintenance Study Group
Feb 25, 2014·Inflammatory Bowel Diseases·Uri KopylovErnest Seidman
Jun 3, 2015·Alimentary Pharmacology & Therapeutics·S Ben-HorinX Roblin
May 18, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gil Y MelmedCorey A Siegel
Jun 15, 2016·The American Journal of Gastroenterology·Parambir S DulaiJean-Frederic Colombel
Aug 7, 2017·Gastroenterology·Joseph D FeuersteinUNKNOWN American Gastroenterological Association Institute Clinical Guidelines Committee

❮ Previous
Next ❯

Citations

Nov 17, 2020·British Journal of Clinical Pharmacology·José María Giráldez-MonteroMaría Jesús Lamas-Díaz
Dec 19, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Reena KhannaBrian G Feagan
Apr 4, 2021·International Journal of Molecular Sciences·Vincent MariauleMoez Rhimi
Jul 10, 2021·Journal of Clinical Gastroenterology·Mahnur Haider, Bret Lashner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Contemporary Internal Medicine
Edward V Loftus, William J Sandborn
The Medical Clinics of North America
Stephen B Hanauer, Filip Baert
Current Opinion in Gastroenterology
David A Leiman, G R Lichtenstein
© 2022 Meta ULC. All rights reserved