Abstract
Protein glycosylation is an important and common post-translational modification. More than 50% of human proteins are believed to be glycosylated to modulate the functionality of proteins. Aberrant glycosylation has been correlated to several diseases, such as inflammatory skin diseases, diabetes mellitus, cardiovascular disorders, rheumatoid arthritis, Alzheimer's and prion diseases, and cancer. Many approved cancer biomarkers are glycoproteins which are not highly abundant proteins. Therefore, effective qualitative and quantitative assessment of glycoproteins entails enrichment methods. This chapter summarizes glycoprotein enrichment methods, including lectin affinity, immunoaffinity, hydrazide chemistry, hydrophilic interaction liquid chromatography, and click chemistry. The use of these enrichment approaches in assessing the qualitative and quantitative changes of glycoproteins in different types of cancers are presented and discussed. This chapter highlights the importance of glycoprotein enrichment techniques for the identification and characterization of new reliable cancer biomarkers.
References
May 20, 2003·Nature Biotechnology·Hui ZhangRuedi Aebersold
Aug 19, 2006·Clinical Chemistry·Ziping YangWilliam S Hancock
Oct 30, 2007·Proteomics·Sun-Hee HeoJe-Yoel Cho
Jul 16, 2008·Journal of Separation Science·Milan MaderaMilos V Novotny
Aug 30, 2008·Journal of Proteome Research·Yanfei WangDavid M Lubman
Mar 19, 2009·Electrophoresis·Piyorot HongsachartShui-Tein Chen
Jun 16, 2009·Journal of Proteome Research·Stephen A WhelanHelena R Chang
Mar 30, 2010·Clinical Chemistry·Evi N DebruyneJoris R Delanghe
Oct 12, 2010·Journal of Proteome Research·Xuemei ZengWilliam L Bigbee
Nov 30, 2010·Cell·Gerald W Hart, Ronald J Copeland
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Feb 23, 2011·Analytical Chemistry·Dongdong WangBarry L Karger
Mar 31, 2011·Molecular & Cellular Proteomics : MCP·Lifang YangO John Semmes
Apr 9, 2011·Molecular & Cellular Proteomics : MCP·Rui ChenHanfa Zou
Apr 20, 2011·Molecular & Cellular Proteomics : MCP·Yingxin ZhaoAllan R Brasier
May 3, 2011·Molecular & Cellular Proteomics : MCP·Jonas BorchJakob Møller-Jensen
May 4, 2011·Proteomics·Hsien-Yu TsaiShui-Tein Chen
Jun 28, 2011·Journal of Proteomics·Takeshi IshiharaYoshito Numata
Jun 23, 2012·Nature Reviews. Molecular Cell Biology·Kelley W MoremenAlison V Nairn
Jun 29, 2012·Electrophoresis·Yehia MechrefAhmed Hussein
Aug 1, 2012·Rapid Communications in Mass Spectrometry : RCM·Ehwang SongYehia Mechref
Jan 8, 2013·Medical Oncology·Xue QinShan Li
May 30, 2013·Proteomics·Jing ChenHui Zhang
Jun 27, 2013·Journal of Proteome Research·Qing Kay LiHui Zhang
Nov 28, 2013·Analytical Chemistry·Anoop MayampurathHaixu Tang
Dec 11, 2013·PloS One·Xianyu LiXiaohong Qian
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jun 20, 2014·Journal of Proteome Research·Anoop MayampurathHaixu Tang
Aug 19, 2014·Journal of Proteome Research·Ehwang SongYehia Mechref
Citations
Nov 1, 2016·Analytical and Bioanalytical Chemistry·Shiyue ZhouYehia Mechref
Apr 27, 2017·Electrophoresis·Petr KozlikMiloslav Sanda
Mar 2, 2016·Molecular & Cellular Proteomics : MCP·Morten Thaysen-AndersenBenjamin L Schulz
Jul 12, 2018·Proteomics. Clinical Applications·Mayank SaraswatSuvi Renkonen
Jan 4, 2019·Mass Spectrometry Reviews·Haopeng XiaoRonghu Wu
Jul 18, 2019·Expert Review of Proteomics·Danielle A Scott, Richard R Drake
Oct 20, 2018·Proteomics. Clinical Applications·Iwona BelczackaVera Jankowski
May 29, 2018·Analytical and Bioanalytical Chemistry·Petr KozlikMiloslav Sanda
Aug 8, 2019·Journal of Separation Science·Hacı Mehmet KayiliBekir Salih
Mar 10, 2016·Electrophoresis·Jingfu ZhaoYehia Mechref
Oct 21, 2016·Electrophoresis·Alireza BanazadehYehia Mechref
Nov 21, 2018·Analytical and Bioanalytical Chemistry·Zeyu SunLanjuan Li
Nov 1, 2020·Communications Biology·Nan-Ee LeeYong-Sam Kim
Jan 5, 2021·Mass Spectrometry Reviews·Ivona Pujić, Hélène Perreault
Jan 6, 2021·Analytical Chemistry·Suttipong SuttapitugsakulRonghu Wu
Feb 7, 2021·Glycoconjugate Journal·Yin-Ling WongYeng Chen
Mar 17, 2021·Mass Spectrometry Reviews·David J Harvey
Apr 21, 2021·Glycoconjugate Journal·Gerda C M VreekerRob A E M Tollenaar
May 23, 2021·Clinics in Laboratory Medicine·Calvin R K BlaschkeRichard R Drake
Jun 20, 2018·Journal of the American Society for Mass Spectrometry·Alireza BanazadehYehia Mechref
Jan 24, 2019·Analytical Chemistry·Luwei ZhangMingliang Ye
Dec 15, 2016·Chemical Reviews·Krishnan K Palaniappan, Carolyn R Bertozzi